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Convergent Evolution of Sodium Ion Selectivity in Metazoan Neuronal Signaling

Ion selectivity of metazoan voltage-gated Na(+) channels is critical for neuronal signaling and has long been attributed to a ring of four conserved amino acids that constitute the ion selectivity filter (SF) at the channel pore. Yet, in addition to channels with a preference for Ca(2+) ions, the ex...

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Detalles Bibliográficos
Autores principales: Gur Barzilai, Maya, Reitzel, Adam M., Kraus, Johanna E.M., Gordon, Dalia, Technau, Ulrich, Gurevitz, Michael, Moran, Yehu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809514/
https://www.ncbi.nlm.nih.gov/pubmed/22854023
http://dx.doi.org/10.1016/j.celrep.2012.06.016