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Determining the Applicability of Threshold of Toxicological Concern Approaches to Substances Found in Foods
Threshold of Toxicological Concern (TTC) decision-support methods present a pragmatic approach to using data from well-characterized chemicals and protective estimates of exposure in a stepwise fashion to inform decisions regarding low-level exposures to chemicals for which few data exist. It is bas...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809586/ https://www.ncbi.nlm.nih.gov/pubmed/24090142 http://dx.doi.org/10.1080/10408398.2012.752341 |
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author | Canady, Richard Lane, Richard Paoli, Greg Wilson, Margaret Bialk, Heidi Hermansky, Steven Kobielush, Brent Lee, Ji-Eun Llewellyn, Craig Scimeca, Joseph |
author_facet | Canady, Richard Lane, Richard Paoli, Greg Wilson, Margaret Bialk, Heidi Hermansky, Steven Kobielush, Brent Lee, Ji-Eun Llewellyn, Craig Scimeca, Joseph |
author_sort | Canady, Richard |
collection | PubMed |
description | Threshold of Toxicological Concern (TTC) decision-support methods present a pragmatic approach to using data from well-characterized chemicals and protective estimates of exposure in a stepwise fashion to inform decisions regarding low-level exposures to chemicals for which few data exist. It is based on structural and functional categorizations of chemicals derived from decades of animal testing with a wide variety of chemicals. Expertise is required to use the TTC methods, and there are situations in which its use is clearly inappropriate or not currently supported. To facilitate proper use of the TTC, this paper describes issues to be considered by risk managers when faced with the situation of an unexpected substance in food. Case studies are provided to illustrate the implementation of these considerations, demonstrating the steps taken in deciding whether it would be appropriate to apply the TTC approach in each case. By appropriately applying the methods, employing the appropriate scientific expertise, and combining use with the conservative assumptions embedded within the derivation of the thresholds, the TTC can realize its potential to protect public health and to contribute to efficient use of resources in food safety risk management. |
format | Online Article Text |
id | pubmed-3809586 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-38095862013-10-29 Determining the Applicability of Threshold of Toxicological Concern Approaches to Substances Found in Foods Canady, Richard Lane, Richard Paoli, Greg Wilson, Margaret Bialk, Heidi Hermansky, Steven Kobielush, Brent Lee, Ji-Eun Llewellyn, Craig Scimeca, Joseph Crit Rev Food Sci Nutr Research Article Threshold of Toxicological Concern (TTC) decision-support methods present a pragmatic approach to using data from well-characterized chemicals and protective estimates of exposure in a stepwise fashion to inform decisions regarding low-level exposures to chemicals for which few data exist. It is based on structural and functional categorizations of chemicals derived from decades of animal testing with a wide variety of chemicals. Expertise is required to use the TTC methods, and there are situations in which its use is clearly inappropriate or not currently supported. To facilitate proper use of the TTC, this paper describes issues to be considered by risk managers when faced with the situation of an unexpected substance in food. Case studies are provided to illustrate the implementation of these considerations, demonstrating the steps taken in deciding whether it would be appropriate to apply the TTC approach in each case. By appropriately applying the methods, employing the appropriate scientific expertise, and combining use with the conservative assumptions embedded within the derivation of the thresholds, the TTC can realize its potential to protect public health and to contribute to efficient use of resources in food safety risk management. Taylor & Francis 2013-10-03 2013-10 /pmc/articles/PMC3809586/ /pubmed/24090142 http://dx.doi.org/10.1080/10408398.2012.752341 Text en Copyright © Taylor and Francis Group, LLC http://www.informaworld.com/mpp/uploads/iopenaccess_tcs.pdf This is an open access article distributed under the Supplemental Terms and Conditions for iOpenAccess articles published in Taylor & Francis journals (http://www.informaworld.com/mpp/uploads/iopenaccess_tcs.pdf) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Canady, Richard Lane, Richard Paoli, Greg Wilson, Margaret Bialk, Heidi Hermansky, Steven Kobielush, Brent Lee, Ji-Eun Llewellyn, Craig Scimeca, Joseph Determining the Applicability of Threshold of Toxicological Concern Approaches to Substances Found in Foods |
title | Determining the Applicability of Threshold of Toxicological Concern Approaches to Substances Found in Foods |
title_full | Determining the Applicability of Threshold of Toxicological Concern Approaches to Substances Found in Foods |
title_fullStr | Determining the Applicability of Threshold of Toxicological Concern Approaches to Substances Found in Foods |
title_full_unstemmed | Determining the Applicability of Threshold of Toxicological Concern Approaches to Substances Found in Foods |
title_short | Determining the Applicability of Threshold of Toxicological Concern Approaches to Substances Found in Foods |
title_sort | determining the applicability of threshold of toxicological concern approaches to substances found in foods |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809586/ https://www.ncbi.nlm.nih.gov/pubmed/24090142 http://dx.doi.org/10.1080/10408398.2012.752341 |
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