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Lymphedema and Therapeutic Lymphangiogenesis

Lymphedema is a disorder of the lymphatic vascular system characterized by impaired lymphatic return and swelling of the extremities. Lymphedema is divided into primary and secondary forms based on the underlying etiology. Despite substantial advances in both surgical and conservative techniques, th...

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Detalles Bibliográficos
Autores principales: Saito, Yukihiro, Nakagami, Hironori, Kaneda, Yasufumi, Morishita, Ryuichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810055/
https://www.ncbi.nlm.nih.gov/pubmed/24222916
http://dx.doi.org/10.1155/2013/804675
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author Saito, Yukihiro
Nakagami, Hironori
Kaneda, Yasufumi
Morishita, Ryuichi
author_facet Saito, Yukihiro
Nakagami, Hironori
Kaneda, Yasufumi
Morishita, Ryuichi
author_sort Saito, Yukihiro
collection PubMed
description Lymphedema is a disorder of the lymphatic vascular system characterized by impaired lymphatic return and swelling of the extremities. Lymphedema is divided into primary and secondary forms based on the underlying etiology. Despite substantial advances in both surgical and conservative techniques, therapeutic options for the management of lymphedema are limited. Although rarely lethal, lymphedema is a disfiguring and disabling condition with an associated decrease in the quality of life. The recent impressive expansion of knowledge on the molecular mechanisms governing lymphangiogenesis provides new possibilities for the treatment of lymphedema. This review highlights the lymphatic biology, the pathophysiology of lymphedema, and the therapeutic lymphangiogenesis using hepatocyte growth factor.
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spelling pubmed-38100552013-11-11 Lymphedema and Therapeutic Lymphangiogenesis Saito, Yukihiro Nakagami, Hironori Kaneda, Yasufumi Morishita, Ryuichi Biomed Res Int Review Article Lymphedema is a disorder of the lymphatic vascular system characterized by impaired lymphatic return and swelling of the extremities. Lymphedema is divided into primary and secondary forms based on the underlying etiology. Despite substantial advances in both surgical and conservative techniques, therapeutic options for the management of lymphedema are limited. Although rarely lethal, lymphedema is a disfiguring and disabling condition with an associated decrease in the quality of life. The recent impressive expansion of knowledge on the molecular mechanisms governing lymphangiogenesis provides new possibilities for the treatment of lymphedema. This review highlights the lymphatic biology, the pathophysiology of lymphedema, and the therapeutic lymphangiogenesis using hepatocyte growth factor. Hindawi Publishing Corporation 2013 2013-10-09 /pmc/articles/PMC3810055/ /pubmed/24222916 http://dx.doi.org/10.1155/2013/804675 Text en Copyright © 2013 Yukihiro Saito et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Saito, Yukihiro
Nakagami, Hironori
Kaneda, Yasufumi
Morishita, Ryuichi
Lymphedema and Therapeutic Lymphangiogenesis
title Lymphedema and Therapeutic Lymphangiogenesis
title_full Lymphedema and Therapeutic Lymphangiogenesis
title_fullStr Lymphedema and Therapeutic Lymphangiogenesis
title_full_unstemmed Lymphedema and Therapeutic Lymphangiogenesis
title_short Lymphedema and Therapeutic Lymphangiogenesis
title_sort lymphedema and therapeutic lymphangiogenesis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810055/
https://www.ncbi.nlm.nih.gov/pubmed/24222916
http://dx.doi.org/10.1155/2013/804675
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