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Lymphedema and Therapeutic Lymphangiogenesis
Lymphedema is a disorder of the lymphatic vascular system characterized by impaired lymphatic return and swelling of the extremities. Lymphedema is divided into primary and secondary forms based on the underlying etiology. Despite substantial advances in both surgical and conservative techniques, th...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810055/ https://www.ncbi.nlm.nih.gov/pubmed/24222916 http://dx.doi.org/10.1155/2013/804675 |
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author | Saito, Yukihiro Nakagami, Hironori Kaneda, Yasufumi Morishita, Ryuichi |
author_facet | Saito, Yukihiro Nakagami, Hironori Kaneda, Yasufumi Morishita, Ryuichi |
author_sort | Saito, Yukihiro |
collection | PubMed |
description | Lymphedema is a disorder of the lymphatic vascular system characterized by impaired lymphatic return and swelling of the extremities. Lymphedema is divided into primary and secondary forms based on the underlying etiology. Despite substantial advances in both surgical and conservative techniques, therapeutic options for the management of lymphedema are limited. Although rarely lethal, lymphedema is a disfiguring and disabling condition with an associated decrease in the quality of life. The recent impressive expansion of knowledge on the molecular mechanisms governing lymphangiogenesis provides new possibilities for the treatment of lymphedema. This review highlights the lymphatic biology, the pathophysiology of lymphedema, and the therapeutic lymphangiogenesis using hepatocyte growth factor. |
format | Online Article Text |
id | pubmed-3810055 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38100552013-11-11 Lymphedema and Therapeutic Lymphangiogenesis Saito, Yukihiro Nakagami, Hironori Kaneda, Yasufumi Morishita, Ryuichi Biomed Res Int Review Article Lymphedema is a disorder of the lymphatic vascular system characterized by impaired lymphatic return and swelling of the extremities. Lymphedema is divided into primary and secondary forms based on the underlying etiology. Despite substantial advances in both surgical and conservative techniques, therapeutic options for the management of lymphedema are limited. Although rarely lethal, lymphedema is a disfiguring and disabling condition with an associated decrease in the quality of life. The recent impressive expansion of knowledge on the molecular mechanisms governing lymphangiogenesis provides new possibilities for the treatment of lymphedema. This review highlights the lymphatic biology, the pathophysiology of lymphedema, and the therapeutic lymphangiogenesis using hepatocyte growth factor. Hindawi Publishing Corporation 2013 2013-10-09 /pmc/articles/PMC3810055/ /pubmed/24222916 http://dx.doi.org/10.1155/2013/804675 Text en Copyright © 2013 Yukihiro Saito et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Saito, Yukihiro Nakagami, Hironori Kaneda, Yasufumi Morishita, Ryuichi Lymphedema and Therapeutic Lymphangiogenesis |
title | Lymphedema and Therapeutic Lymphangiogenesis |
title_full | Lymphedema and Therapeutic Lymphangiogenesis |
title_fullStr | Lymphedema and Therapeutic Lymphangiogenesis |
title_full_unstemmed | Lymphedema and Therapeutic Lymphangiogenesis |
title_short | Lymphedema and Therapeutic Lymphangiogenesis |
title_sort | lymphedema and therapeutic lymphangiogenesis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810055/ https://www.ncbi.nlm.nih.gov/pubmed/24222916 http://dx.doi.org/10.1155/2013/804675 |
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