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Expression and Clinical Significance of Livin Protein in Hepatocellular Carcinoma

In this study, the two-step PV method of immunohistochemistry was used to determine livin protein expression in HCC tissues, pericarcinoma tissues, hepatitis/hepatic cirrhosis tissues, and normal hepatic tissues, and livin protein expression was detected in the blood plasma of patients with HCC befo...

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Autores principales: Guo, Hua, Gao, Ying-tang, Zhang, Qin, Jing, Li, Liu, Tong, Shi, Wen-xia, Zhai, Dao-kuan, Jing, Xiang, Du, Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810112/
https://www.ncbi.nlm.nih.gov/pubmed/24223461
http://dx.doi.org/10.1155/2013/781740
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author Guo, Hua
Gao, Ying-tang
Zhang, Qin
Jing, Li
Liu, Tong
Shi, Wen-xia
Zhai, Dao-kuan
Jing, Xiang
Du, Zhi
author_facet Guo, Hua
Gao, Ying-tang
Zhang, Qin
Jing, Li
Liu, Tong
Shi, Wen-xia
Zhai, Dao-kuan
Jing, Xiang
Du, Zhi
author_sort Guo, Hua
collection PubMed
description In this study, the two-step PV method of immunohistochemistry was used to determine livin protein expression in HCC tissues, pericarcinoma tissues, hepatitis/hepatic cirrhosis tissues, and normal hepatic tissues, and livin protein expression was detected in the blood plasma of patients with HCC before and after surgery, subjects with hepatic cirrhosis and hepatitis, and healthy blood donors using ELISA. Livin protein expression was significantly higher in HCC tissues than that in normal hepatic tissues and hepatitis/hepatic cirrhosis tissues, with no significant difference between HCC tissues and pericarcinoma tissues. The HCC patients with positive livin protein expression had a significantly higher survival rate than those with negative livin protein expression. Livin protein expression was significantly higher in the blood plasma of patients with HCC before and after surgery and in patients with hepatic cirrhosis and hepatitis than that in healthy blood donors, whereas livin protein expression in the blood plasma of patients with HCC was not significantly different from that of patients with hepatic cirrhosis and hepatitis. Livin protein expression in HCC tissues did not correlate with that in the blood plasma of the same HCC patients. Livin protein expression may be a potential, effective indicator for assessing prognosis in patients with HCC.
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spelling pubmed-38101122013-11-10 Expression and Clinical Significance of Livin Protein in Hepatocellular Carcinoma Guo, Hua Gao, Ying-tang Zhang, Qin Jing, Li Liu, Tong Shi, Wen-xia Zhai, Dao-kuan Jing, Xiang Du, Zhi Dis Markers Research Article In this study, the two-step PV method of immunohistochemistry was used to determine livin protein expression in HCC tissues, pericarcinoma tissues, hepatitis/hepatic cirrhosis tissues, and normal hepatic tissues, and livin protein expression was detected in the blood plasma of patients with HCC before and after surgery, subjects with hepatic cirrhosis and hepatitis, and healthy blood donors using ELISA. Livin protein expression was significantly higher in HCC tissues than that in normal hepatic tissues and hepatitis/hepatic cirrhosis tissues, with no significant difference between HCC tissues and pericarcinoma tissues. The HCC patients with positive livin protein expression had a significantly higher survival rate than those with negative livin protein expression. Livin protein expression was significantly higher in the blood plasma of patients with HCC before and after surgery and in patients with hepatic cirrhosis and hepatitis than that in healthy blood donors, whereas livin protein expression in the blood plasma of patients with HCC was not significantly different from that of patients with hepatic cirrhosis and hepatitis. Livin protein expression in HCC tissues did not correlate with that in the blood plasma of the same HCC patients. Livin protein expression may be a potential, effective indicator for assessing prognosis in patients with HCC. Hindawi Publishing Corporation 2013 2013-10-03 /pmc/articles/PMC3810112/ /pubmed/24223461 http://dx.doi.org/10.1155/2013/781740 Text en Copyright © 2013 Hua Guo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Guo, Hua
Gao, Ying-tang
Zhang, Qin
Jing, Li
Liu, Tong
Shi, Wen-xia
Zhai, Dao-kuan
Jing, Xiang
Du, Zhi
Expression and Clinical Significance of Livin Protein in Hepatocellular Carcinoma
title Expression and Clinical Significance of Livin Protein in Hepatocellular Carcinoma
title_full Expression and Clinical Significance of Livin Protein in Hepatocellular Carcinoma
title_fullStr Expression and Clinical Significance of Livin Protein in Hepatocellular Carcinoma
title_full_unstemmed Expression and Clinical Significance of Livin Protein in Hepatocellular Carcinoma
title_short Expression and Clinical Significance of Livin Protein in Hepatocellular Carcinoma
title_sort expression and clinical significance of livin protein in hepatocellular carcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810112/
https://www.ncbi.nlm.nih.gov/pubmed/24223461
http://dx.doi.org/10.1155/2013/781740
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