Inhibitory Effects of Trypanosoma cruzi Sialoglycoproteins on CD4(+) T Cells Are Associated with Increased Susceptibility to Infection

BACKGROUND: The Trypanosoma cruzi infection is associated with severe T cell unresponsiveness to antigens and mitogens characterized by decreased IL-2 synthesis. Trypanosoma cruzi mucin (Tc Muc) has been implicated in this phenomenom. These molecules contain a unique type of glycosylation consisting...

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Detalles Bibliográficos
Autores principales: Nunes, Marise Pinheiro, Fortes, Bárbara, Silva-Filho, João Luiz, Terra-Granado, Eugênia, Santos, Leonardo, Conde, Luciana, de Araújo Oliveira, Isadora, Freire-de-Lima, Leonardo, Martins, Marina Vieira, Pinheiro, Ana Acacia Sá, Takyia, Christina Maeda, Freire-de-Lima, Célio Geraldo, Todeschini, Adriane Regina, DosReis, George Alexandre, Morrot, Alexandre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810146/
https://www.ncbi.nlm.nih.gov/pubmed/24204874
http://dx.doi.org/10.1371/journal.pone.0077568

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