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Estimate of CRP and TNF-alpha level before and after periodontal therapy in cardiovascular disease patients
INTRODUCTION: Epidemiological studies show that individuals with periodontitis have a radically amplified threat to develop cardiovascular disease. CRP& TNF-α, are acute phase proteins monitored as a marker of inflammatory status, which have been identified as a major risk factor for atheroscler...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The African Field Epidemiology Network
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810246/ https://www.ncbi.nlm.nih.gov/pubmed/24198887 http://dx.doi.org/10.11604/pamj.2013.15.92.2326 |
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author | Koppolu, Pradeep Durvasula, Satyanarayana Palaparthy, Rajababu Rao, Mukhesh Sagar, Vidya Reddy, Sunil Kumar Lingam, Swapna |
author_facet | Koppolu, Pradeep Durvasula, Satyanarayana Palaparthy, Rajababu Rao, Mukhesh Sagar, Vidya Reddy, Sunil Kumar Lingam, Swapna |
author_sort | Koppolu, Pradeep |
collection | PubMed |
description | INTRODUCTION: Epidemiological studies show that individuals with periodontitis have a radically amplified threat to develop cardiovascular disease. CRP& TNF-α, are acute phase proteins monitored as a marker of inflammatory status, which have been identified as a major risk factor for atherosclerotic complications. Elevated CRP & TNF-α level in periodontitis patients have been reported by several groups. The present study was performed to determine whether presence of periodontitis and periodontal therapy could influence the serum levels of CRP & TNF-α in cardiovascular disease patients. METHODS: Forty cardiovascular disease subjects participated in the study. They were classified into two groups. Group A (Control) where no periodontal treatment was given, Group B (Test) where periodontal treatment (scaling & root planing) was performed. Periodontal clinical parameters like OHI-S, probing pocket depth, were evaluated together with serum CRP, TNF-α, at baseline and reassessed after 8 weeks for all the subjects in both the groups. RESULTS: The CRP & TNF-α levels in both the groups decreased but the decrease in the Group A was minimal and was not statistically significant (P > 0.05); whereas in Group B where periodontal therapy was performed, there was statistically significant decrease. CONCLUSION: It can be concluded from the study that there can be a possible causal relationship between pathogenesis of periodontal disease and CVD as inferred from the statistical significant outcome in the form of decreased inflammatory biomarkers after the periodontal treatment. |
format | Online Article Text |
id | pubmed-3810246 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | The African Field Epidemiology Network |
record_format | MEDLINE/PubMed |
spelling | pubmed-38102462013-11-06 Estimate of CRP and TNF-alpha level before and after periodontal therapy in cardiovascular disease patients Koppolu, Pradeep Durvasula, Satyanarayana Palaparthy, Rajababu Rao, Mukhesh Sagar, Vidya Reddy, Sunil Kumar Lingam, Swapna Pan Afr Med J Research INTRODUCTION: Epidemiological studies show that individuals with periodontitis have a radically amplified threat to develop cardiovascular disease. CRP& TNF-α, are acute phase proteins monitored as a marker of inflammatory status, which have been identified as a major risk factor for atherosclerotic complications. Elevated CRP & TNF-α level in periodontitis patients have been reported by several groups. The present study was performed to determine whether presence of periodontitis and periodontal therapy could influence the serum levels of CRP & TNF-α in cardiovascular disease patients. METHODS: Forty cardiovascular disease subjects participated in the study. They were classified into two groups. Group A (Control) where no periodontal treatment was given, Group B (Test) where periodontal treatment (scaling & root planing) was performed. Periodontal clinical parameters like OHI-S, probing pocket depth, were evaluated together with serum CRP, TNF-α, at baseline and reassessed after 8 weeks for all the subjects in both the groups. RESULTS: The CRP & TNF-α levels in both the groups decreased but the decrease in the Group A was minimal and was not statistically significant (P > 0.05); whereas in Group B where periodontal therapy was performed, there was statistically significant decrease. CONCLUSION: It can be concluded from the study that there can be a possible causal relationship between pathogenesis of periodontal disease and CVD as inferred from the statistical significant outcome in the form of decreased inflammatory biomarkers after the periodontal treatment. The African Field Epidemiology Network 2013-07-10 /pmc/articles/PMC3810246/ /pubmed/24198887 http://dx.doi.org/10.11604/pamj.2013.15.92.2326 Text en © Pradeep Koppolu et al. http://creativecommons.org/licenses/by/2.0/ The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Koppolu, Pradeep Durvasula, Satyanarayana Palaparthy, Rajababu Rao, Mukhesh Sagar, Vidya Reddy, Sunil Kumar Lingam, Swapna Estimate of CRP and TNF-alpha level before and after periodontal therapy in cardiovascular disease patients |
title | Estimate of CRP and TNF-alpha level before and after periodontal therapy in cardiovascular disease patients |
title_full | Estimate of CRP and TNF-alpha level before and after periodontal therapy in cardiovascular disease patients |
title_fullStr | Estimate of CRP and TNF-alpha level before and after periodontal therapy in cardiovascular disease patients |
title_full_unstemmed | Estimate of CRP and TNF-alpha level before and after periodontal therapy in cardiovascular disease patients |
title_short | Estimate of CRP and TNF-alpha level before and after periodontal therapy in cardiovascular disease patients |
title_sort | estimate of crp and tnf-alpha level before and after periodontal therapy in cardiovascular disease patients |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810246/ https://www.ncbi.nlm.nih.gov/pubmed/24198887 http://dx.doi.org/10.11604/pamj.2013.15.92.2326 |
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