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Estimate of CRP and TNF-alpha level before and after periodontal therapy in cardiovascular disease patients

INTRODUCTION: Epidemiological studies show that individuals with periodontitis have a radically amplified threat to develop cardiovascular disease. CRP& TNF-α, are acute phase proteins monitored as a marker of inflammatory status, which have been identified as a major risk factor for atheroscler...

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Autores principales: Koppolu, Pradeep, Durvasula, Satyanarayana, Palaparthy, Rajababu, Rao, Mukhesh, Sagar, Vidya, Reddy, Sunil Kumar, Lingam, Swapna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The African Field Epidemiology Network 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810246/
https://www.ncbi.nlm.nih.gov/pubmed/24198887
http://dx.doi.org/10.11604/pamj.2013.15.92.2326
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author Koppolu, Pradeep
Durvasula, Satyanarayana
Palaparthy, Rajababu
Rao, Mukhesh
Sagar, Vidya
Reddy, Sunil Kumar
Lingam, Swapna
author_facet Koppolu, Pradeep
Durvasula, Satyanarayana
Palaparthy, Rajababu
Rao, Mukhesh
Sagar, Vidya
Reddy, Sunil Kumar
Lingam, Swapna
author_sort Koppolu, Pradeep
collection PubMed
description INTRODUCTION: Epidemiological studies show that individuals with periodontitis have a radically amplified threat to develop cardiovascular disease. CRP& TNF-α, are acute phase proteins monitored as a marker of inflammatory status, which have been identified as a major risk factor for atherosclerotic complications. Elevated CRP & TNF-α level in periodontitis patients have been reported by several groups. The present study was performed to determine whether presence of periodontitis and periodontal therapy could influence the serum levels of CRP & TNF-α in cardiovascular disease patients. METHODS: Forty cardiovascular disease subjects participated in the study. They were classified into two groups. Group A (Control) where no periodontal treatment was given, Group B (Test) where periodontal treatment (scaling & root planing) was performed. Periodontal clinical parameters like OHI-S, probing pocket depth, were evaluated together with serum CRP, TNF-α, at baseline and reassessed after 8 weeks for all the subjects in both the groups. RESULTS: The CRP & TNF-α levels in both the groups decreased but the decrease in the Group A was minimal and was not statistically significant (P > 0.05); whereas in Group B where periodontal therapy was performed, there was statistically significant decrease. CONCLUSION: It can be concluded from the study that there can be a possible causal relationship between pathogenesis of periodontal disease and CVD as inferred from the statistical significant outcome in the form of decreased inflammatory biomarkers after the periodontal treatment.
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spelling pubmed-38102462013-11-06 Estimate of CRP and TNF-alpha level before and after periodontal therapy in cardiovascular disease patients Koppolu, Pradeep Durvasula, Satyanarayana Palaparthy, Rajababu Rao, Mukhesh Sagar, Vidya Reddy, Sunil Kumar Lingam, Swapna Pan Afr Med J Research INTRODUCTION: Epidemiological studies show that individuals with periodontitis have a radically amplified threat to develop cardiovascular disease. CRP& TNF-α, are acute phase proteins monitored as a marker of inflammatory status, which have been identified as a major risk factor for atherosclerotic complications. Elevated CRP & TNF-α level in periodontitis patients have been reported by several groups. The present study was performed to determine whether presence of periodontitis and periodontal therapy could influence the serum levels of CRP & TNF-α in cardiovascular disease patients. METHODS: Forty cardiovascular disease subjects participated in the study. They were classified into two groups. Group A (Control) where no periodontal treatment was given, Group B (Test) where periodontal treatment (scaling & root planing) was performed. Periodontal clinical parameters like OHI-S, probing pocket depth, were evaluated together with serum CRP, TNF-α, at baseline and reassessed after 8 weeks for all the subjects in both the groups. RESULTS: The CRP & TNF-α levels in both the groups decreased but the decrease in the Group A was minimal and was not statistically significant (P > 0.05); whereas in Group B where periodontal therapy was performed, there was statistically significant decrease. CONCLUSION: It can be concluded from the study that there can be a possible causal relationship between pathogenesis of periodontal disease and CVD as inferred from the statistical significant outcome in the form of decreased inflammatory biomarkers after the periodontal treatment. The African Field Epidemiology Network 2013-07-10 /pmc/articles/PMC3810246/ /pubmed/24198887 http://dx.doi.org/10.11604/pamj.2013.15.92.2326 Text en © Pradeep Koppolu et al. http://creativecommons.org/licenses/by/2.0/ The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Koppolu, Pradeep
Durvasula, Satyanarayana
Palaparthy, Rajababu
Rao, Mukhesh
Sagar, Vidya
Reddy, Sunil Kumar
Lingam, Swapna
Estimate of CRP and TNF-alpha level before and after periodontal therapy in cardiovascular disease patients
title Estimate of CRP and TNF-alpha level before and after periodontal therapy in cardiovascular disease patients
title_full Estimate of CRP and TNF-alpha level before and after periodontal therapy in cardiovascular disease patients
title_fullStr Estimate of CRP and TNF-alpha level before and after periodontal therapy in cardiovascular disease patients
title_full_unstemmed Estimate of CRP and TNF-alpha level before and after periodontal therapy in cardiovascular disease patients
title_short Estimate of CRP and TNF-alpha level before and after periodontal therapy in cardiovascular disease patients
title_sort estimate of crp and tnf-alpha level before and after periodontal therapy in cardiovascular disease patients
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810246/
https://www.ncbi.nlm.nih.gov/pubmed/24198887
http://dx.doi.org/10.11604/pamj.2013.15.92.2326
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