The dual role of IRF8 in cancer immunosurveillance

For a long time, the transcription factor interferon-regulatory factor 8 (IRF8) has been recognized as a masterpiece for the development of myeloid cells, and its role as a central regulator of immune responses has now been clarified. IRF8 is also critical for tumor progression, suggesting its funda...

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Detalles Bibliográficos
Autores principales: Schiavoni, Giovanna, Gabriele, Lucia, Mattei, Fabrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810266/
https://www.ncbi.nlm.nih.gov/pubmed/24175153
http://dx.doi.org/10.4161/onci.25476
Descripción
Sumario:For a long time, the transcription factor interferon-regulatory factor 8 (IRF8) has been recognized as a masterpiece for the development of myeloid cells, and its role as a central regulator of immune responses has now been clarified. IRF8 is also critical for tumor progression, suggesting its fundamental relevance in multiple aspects of cancer immunosurveillance.

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