Slow Proton Transfer Coupled to Unfolding Explains the Puzzling Results of Single-Molecule Experiments on BBL, a Paradigmatic Downhill Folding Protein

A battery of thermodynamic, kinetic, and structural approaches has indicated that the small α-helical protein BBL folds-unfolds via the one-state downhill scenario. Yet, single-molecule fluorescence spectroscopy offers a more conflicting view. Single-molecule experiments at pH 6 show a unique half-u...

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Detalles Bibliográficos
Autores principales: Cerminara, Michele, Campos, Luis A., Ramanathan, Ravishankar, Muñoz, Victor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810382/
https://www.ncbi.nlm.nih.gov/pubmed/24205082
http://dx.doi.org/10.1371/journal.pone.0078044

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