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Correcting for Population Structure and Kinship Using the Linear Mixed Model: Theory and Extensions
Population structure and kinship are widespread confounding factors in genome-wide association studies (GWAS). It has been standard practice to include principal components of the genotypes in a regression model in order to account for population structure. More recently, the linear mixed model (LMM...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810480/ https://www.ncbi.nlm.nih.gov/pubmed/24204578 http://dx.doi.org/10.1371/journal.pone.0075707 |