A model for prediction of cisplatin induced nephrotoxicity by kidney weight in experimental rats

BACKGROUND: Cisplatin (cis-diamminedichloroplatinum II; CP) is used widely as an antitumor drug in clinics, but is accompanied with renal toxicity. Cisplatin induced nephrotoxicity consists of change in kidney weight, histological changes in kidney and increase in serum creatinine (Cr) and blood ure...

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Autores principales: Nematbakhsh, Mehdi, Ashrafi, Farzaneh, Nasri, Hamid, Talebi, Ardeshir, Pezeshki, Zahra, Eshraghi, Fatemeh, Haghighi, Maryam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810567/
https://www.ncbi.nlm.nih.gov/pubmed/24174938
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author Nematbakhsh, Mehdi
Ashrafi, Farzaneh
Nasri, Hamid
Talebi, Ardeshir
Pezeshki, Zahra
Eshraghi, Fatemeh
Haghighi, Maryam
author_facet Nematbakhsh, Mehdi
Ashrafi, Farzaneh
Nasri, Hamid
Talebi, Ardeshir
Pezeshki, Zahra
Eshraghi, Fatemeh
Haghighi, Maryam
author_sort Nematbakhsh, Mehdi
collection PubMed
description BACKGROUND: Cisplatin (cis-diamminedichloroplatinum II; CP) is used widely as an antitumor drug in clinics, but is accompanied with renal toxicity. Cisplatin induced nephrotoxicity consists of change in kidney weight, histological changes in kidney and increase in serum creatinine (Cr) and blood urea nitrogen (BUN). This study was designed to find out a model for prediction of cisplatin induced nephrotoxicity. MATERIALS AND METHODS: Pathological damage score, kidney weight, BUN, and Cr of 227 rats that were involved in different projects were determined. A total of 187 rats were treated with 7 mg/kg cisplatin and sacrificed 1 week later. RESULTS: There was a good significant correlation between normalized kidney weight and logarithmic scale of BUN and Cr. Relationship between BUN, Cr or normalized kidney weight and pathology damage score was significant. CONCLUSION: Normalized kidney weight and pathology damage score is a good predictor of renal function in cisplatin induced nephrotoxicity in experimental rats.
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spelling pubmed-38105672013-10-30 A model for prediction of cisplatin induced nephrotoxicity by kidney weight in experimental rats Nematbakhsh, Mehdi Ashrafi, Farzaneh Nasri, Hamid Talebi, Ardeshir Pezeshki, Zahra Eshraghi, Fatemeh Haghighi, Maryam J Res Med Sci Original Article BACKGROUND: Cisplatin (cis-diamminedichloroplatinum II; CP) is used widely as an antitumor drug in clinics, but is accompanied with renal toxicity. Cisplatin induced nephrotoxicity consists of change in kidney weight, histological changes in kidney and increase in serum creatinine (Cr) and blood urea nitrogen (BUN). This study was designed to find out a model for prediction of cisplatin induced nephrotoxicity. MATERIALS AND METHODS: Pathological damage score, kidney weight, BUN, and Cr of 227 rats that were involved in different projects were determined. A total of 187 rats were treated with 7 mg/kg cisplatin and sacrificed 1 week later. RESULTS: There was a good significant correlation between normalized kidney weight and logarithmic scale of BUN and Cr. Relationship between BUN, Cr or normalized kidney weight and pathology damage score was significant. CONCLUSION: Normalized kidney weight and pathology damage score is a good predictor of renal function in cisplatin induced nephrotoxicity in experimental rats. Medknow Publications & Media Pvt Ltd 2013-05 /pmc/articles/PMC3810567/ /pubmed/24174938 Text en Copyright: © Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Nematbakhsh, Mehdi
Ashrafi, Farzaneh
Nasri, Hamid
Talebi, Ardeshir
Pezeshki, Zahra
Eshraghi, Fatemeh
Haghighi, Maryam
A model for prediction of cisplatin induced nephrotoxicity by kidney weight in experimental rats
title A model for prediction of cisplatin induced nephrotoxicity by kidney weight in experimental rats
title_full A model for prediction of cisplatin induced nephrotoxicity by kidney weight in experimental rats
title_fullStr A model for prediction of cisplatin induced nephrotoxicity by kidney weight in experimental rats
title_full_unstemmed A model for prediction of cisplatin induced nephrotoxicity by kidney weight in experimental rats
title_short A model for prediction of cisplatin induced nephrotoxicity by kidney weight in experimental rats
title_sort model for prediction of cisplatin induced nephrotoxicity by kidney weight in experimental rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810567/
https://www.ncbi.nlm.nih.gov/pubmed/24174938
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