GWAS meta analysis identifies TSNARE1 as a novel Schizophrenia / Bipolar susceptibility locus

We carried out a GWAS meta-analysis of combined mixed-ancestry schizophrenia, schizoaffective, and bipolar cohorts that resulted in the identification of six genome-wide significant loci, including one novel locus at chr8q24.3, encompassing TSNARE1 (P = 1.28 × 10(−9)). The analysis included a total...

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Detalles Bibliográficos
Autores principales: Sleiman, Patrick, Wang, Dai, Glessner, Joseph, Hadley, Dexter, Gur, Raquel E., Cohen, Nadine, Li, Qingqin, Hakonarson, Hakon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810676/
https://www.ncbi.nlm.nih.gov/pubmed/24166486
http://dx.doi.org/10.1038/srep03075
Descripción
Sumario:We carried out a GWAS meta-analysis of combined mixed-ancestry schizophrenia, schizoaffective, and bipolar cohorts that resulted in the identification of six genome-wide significant loci, including one novel locus at chr8q24.3, encompassing TSNARE1 (P = 1.28 × 10(−9)). The analysis included a total of 13,394 cases and 34,676 controls. While the function of TSNARE1 remains unknown, bioinformatic predictions based on phylogenetic ancestry indicate it may have a vertebrate-specific function in intracellular protein transport and synaptic vesicle exocytosis.

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