GWAS meta analysis identifies TSNARE1 as a novel Schizophrenia / Bipolar susceptibility locus

We carried out a GWAS meta-analysis of combined mixed-ancestry schizophrenia, schizoaffective, and bipolar cohorts that resulted in the identification of six genome-wide significant loci, including one novel locus at chr8q24.3, encompassing TSNARE1 (P = 1.28 × 10(−9)). The analysis included a total...

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Detalles Bibliográficos
Autores principales: Sleiman, Patrick, Wang, Dai, Glessner, Joseph, Hadley, Dexter, Gur, Raquel E., Cohen, Nadine, Li, Qingqin, Hakonarson, Hakon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810676/
https://www.ncbi.nlm.nih.gov/pubmed/24166486
http://dx.doi.org/10.1038/srep03075
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author Sleiman, Patrick
Wang, Dai
Glessner, Joseph
Hadley, Dexter
Gur, Raquel E.
Cohen, Nadine
Li, Qingqin
Hakonarson, Hakon
author_facet Sleiman, Patrick
Wang, Dai
Glessner, Joseph
Hadley, Dexter
Gur, Raquel E.
Cohen, Nadine
Li, Qingqin
Hakonarson, Hakon
author_sort Sleiman, Patrick
collection PubMed
description We carried out a GWAS meta-analysis of combined mixed-ancestry schizophrenia, schizoaffective, and bipolar cohorts that resulted in the identification of six genome-wide significant loci, including one novel locus at chr8q24.3, encompassing TSNARE1 (P = 1.28 × 10(−9)). The analysis included a total of 13,394 cases and 34,676 controls. While the function of TSNARE1 remains unknown, bioinformatic predictions based on phylogenetic ancestry indicate it may have a vertebrate-specific function in intracellular protein transport and synaptic vesicle exocytosis.
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spelling pubmed-38106762013-10-29 GWAS meta analysis identifies TSNARE1 as a novel Schizophrenia / Bipolar susceptibility locus Sleiman, Patrick Wang, Dai Glessner, Joseph Hadley, Dexter Gur, Raquel E. Cohen, Nadine Li, Qingqin Hakonarson, Hakon Sci Rep Article We carried out a GWAS meta-analysis of combined mixed-ancestry schizophrenia, schizoaffective, and bipolar cohorts that resulted in the identification of six genome-wide significant loci, including one novel locus at chr8q24.3, encompassing TSNARE1 (P = 1.28 × 10(−9)). The analysis included a total of 13,394 cases and 34,676 controls. While the function of TSNARE1 remains unknown, bioinformatic predictions based on phylogenetic ancestry indicate it may have a vertebrate-specific function in intracellular protein transport and synaptic vesicle exocytosis. Nature Publishing Group 2013-10-29 /pmc/articles/PMC3810676/ /pubmed/24166486 http://dx.doi.org/10.1038/srep03075 Text en Copyright © 2013, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Article
Sleiman, Patrick
Wang, Dai
Glessner, Joseph
Hadley, Dexter
Gur, Raquel E.
Cohen, Nadine
Li, Qingqin
Hakonarson, Hakon
GWAS meta analysis identifies TSNARE1 as a novel Schizophrenia / Bipolar susceptibility locus
title GWAS meta analysis identifies TSNARE1 as a novel Schizophrenia / Bipolar susceptibility locus
title_full GWAS meta analysis identifies TSNARE1 as a novel Schizophrenia / Bipolar susceptibility locus
title_fullStr GWAS meta analysis identifies TSNARE1 as a novel Schizophrenia / Bipolar susceptibility locus
title_full_unstemmed GWAS meta analysis identifies TSNARE1 as a novel Schizophrenia / Bipolar susceptibility locus
title_short GWAS meta analysis identifies TSNARE1 as a novel Schizophrenia / Bipolar susceptibility locus
title_sort gwas meta analysis identifies tsnare1 as a novel schizophrenia / bipolar susceptibility locus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810676/
https://www.ncbi.nlm.nih.gov/pubmed/24166486
http://dx.doi.org/10.1038/srep03075
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