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A Songbird Animal Model for Dissecting the Genetic Bases of Autism Spectrum Disorder

The neural and genetic bases of human language development and associated neurodevelopmental disorders, including autism spectrum disorder (ASD), in which language impairment represents a core deficit, are poorly understood. Given that no single animal model can fully capture the behavioral and gene...

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Detalles Bibliográficos
Autor principal: Panaitof, S. Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810686/
https://www.ncbi.nlm.nih.gov/pubmed/22960335
http://dx.doi.org/10.3233/DMA-2012-0918
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author Panaitof, S. Carmen
author_facet Panaitof, S. Carmen
author_sort Panaitof, S. Carmen
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description The neural and genetic bases of human language development and associated neurodevelopmental disorders, including autism spectrum disorder (ASD), in which language impairment represents a core deficit, are poorly understood. Given that no single animal model can fully capture the behavioral and genetic complexity of ASD, work in songbird, an experimentally tractable animal model of vocal learning, can complement the valuable tool of rodent genetic models and contribute important insights to our understanding of the communication deficits observed in ASD. Like humans, but unlike traditional laboratory animals such as rodents or non-human primates, songbirds exhibit the capacity of vocal learning, a key subcomponent of language. Human speech and birdsong reveal important parallels, highlighting similar developmental critical periods, a homologous cortico-basal ganglia-thalamic circuitry, and a critical role for social influences in the learning of vocalizations. Here I highlight recent advances in using the songbird model to probe the cellular and molecular mechanisms underlying the formation and function of neural circuitry for birdsong and, by analogy, human language, with the ultimate goal of identifying any shared or human unique biological pathways underscoring language development and its disruption in ASD.
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spelling pubmed-38106862013-12-10 A Songbird Animal Model for Dissecting the Genetic Bases of Autism Spectrum Disorder Panaitof, S. Carmen Dis Markers Other The neural and genetic bases of human language development and associated neurodevelopmental disorders, including autism spectrum disorder (ASD), in which language impairment represents a core deficit, are poorly understood. Given that no single animal model can fully capture the behavioral and genetic complexity of ASD, work in songbird, an experimentally tractable animal model of vocal learning, can complement the valuable tool of rodent genetic models and contribute important insights to our understanding of the communication deficits observed in ASD. Like humans, but unlike traditional laboratory animals such as rodents or non-human primates, songbirds exhibit the capacity of vocal learning, a key subcomponent of language. Human speech and birdsong reveal important parallels, highlighting similar developmental critical periods, a homologous cortico-basal ganglia-thalamic circuitry, and a critical role for social influences in the learning of vocalizations. Here I highlight recent advances in using the songbird model to probe the cellular and molecular mechanisms underlying the formation and function of neural circuitry for birdsong and, by analogy, human language, with the ultimate goal of identifying any shared or human unique biological pathways underscoring language development and its disruption in ASD. IOS Press 2012 2012-12-05 /pmc/articles/PMC3810686/ /pubmed/22960335 http://dx.doi.org/10.3233/DMA-2012-0918 Text en Copyright © 2012 Hindawi Publishing Corporation.
spellingShingle Other
Panaitof, S. Carmen
A Songbird Animal Model for Dissecting the Genetic Bases of Autism Spectrum Disorder
title A Songbird Animal Model for Dissecting the Genetic Bases of Autism Spectrum Disorder
title_full A Songbird Animal Model for Dissecting the Genetic Bases of Autism Spectrum Disorder
title_fullStr A Songbird Animal Model for Dissecting the Genetic Bases of Autism Spectrum Disorder
title_full_unstemmed A Songbird Animal Model for Dissecting the Genetic Bases of Autism Spectrum Disorder
title_short A Songbird Animal Model for Dissecting the Genetic Bases of Autism Spectrum Disorder
title_sort songbird animal model for dissecting the genetic bases of autism spectrum disorder
topic Other
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810686/
https://www.ncbi.nlm.nih.gov/pubmed/22960335
http://dx.doi.org/10.3233/DMA-2012-0918
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