Cargando…

Genetic Recombination and Cryptosporidium hominis Virulent Subtype IbA10G2

Little is known about the emergence and spread of virulent subtypes of Cryptosporidium hominis, the predominant species responsible for human cryptosporidiosis. We conducted sequence analyses of 32 genetic loci of 53 C. hominis specimens isolated from a longitudinally followed cohort of children liv...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Na, Xiao, Lihua, Cama, Vitaliano A., Ortega, Ynes, Gilman, Robert H., Guo, Meijin, Feng, Yaoyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810731/
https://www.ncbi.nlm.nih.gov/pubmed/24050210
http://dx.doi.org/10.3201/eid1910.121361
_version_ 1782288846013071360
author Li, Na
Xiao, Lihua
Cama, Vitaliano A.
Ortega, Ynes
Gilman, Robert H.
Guo, Meijin
Feng, Yaoyu
author_facet Li, Na
Xiao, Lihua
Cama, Vitaliano A.
Ortega, Ynes
Gilman, Robert H.
Guo, Meijin
Feng, Yaoyu
author_sort Li, Na
collection PubMed
description Little is known about the emergence and spread of virulent subtypes of Cryptosporidium hominis, the predominant species responsible for human cryptosporidiosis. We conducted sequence analyses of 32 genetic loci of 53 C. hominis specimens isolated from a longitudinally followed cohort of children living in a small community. We identified by linkage disequilibrium and recombination analyses only limited genetic recombination, which occurred exclusively within the 60-kDa glycoprotein gene subtype IbA10G2, a predominant subtype for outbreaks in industrialized nations and a virulent subtype in the study community. Intensive transmission of virulent subtype IbA10G2 in the study area might have resulted in genetic recombination with other subtypes. Moreover, we identified selection for IbA10G2 at a 129-kb region around the 60-kDa glycoprotein gene in chromosome 6. These findings improve our understanding of the origin and evolution of C. hominis subtypes and the spread of virulent subtypes.
format Online
Article
Text
id pubmed-3810731
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Centers for Disease Control and Prevention
record_format MEDLINE/PubMed
spelling pubmed-38107312013-11-05 Genetic Recombination and Cryptosporidium hominis Virulent Subtype IbA10G2 Li, Na Xiao, Lihua Cama, Vitaliano A. Ortega, Ynes Gilman, Robert H. Guo, Meijin Feng, Yaoyu Emerg Infect Dis Research Little is known about the emergence and spread of virulent subtypes of Cryptosporidium hominis, the predominant species responsible for human cryptosporidiosis. We conducted sequence analyses of 32 genetic loci of 53 C. hominis specimens isolated from a longitudinally followed cohort of children living in a small community. We identified by linkage disequilibrium and recombination analyses only limited genetic recombination, which occurred exclusively within the 60-kDa glycoprotein gene subtype IbA10G2, a predominant subtype for outbreaks in industrialized nations and a virulent subtype in the study community. Intensive transmission of virulent subtype IbA10G2 in the study area might have resulted in genetic recombination with other subtypes. Moreover, we identified selection for IbA10G2 at a 129-kb region around the 60-kDa glycoprotein gene in chromosome 6. These findings improve our understanding of the origin and evolution of C. hominis subtypes and the spread of virulent subtypes. Centers for Disease Control and Prevention 2013-10 /pmc/articles/PMC3810731/ /pubmed/24050210 http://dx.doi.org/10.3201/eid1910.121361 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Li, Na
Xiao, Lihua
Cama, Vitaliano A.
Ortega, Ynes
Gilman, Robert H.
Guo, Meijin
Feng, Yaoyu
Genetic Recombination and Cryptosporidium hominis Virulent Subtype IbA10G2
title Genetic Recombination and Cryptosporidium hominis Virulent Subtype IbA10G2
title_full Genetic Recombination and Cryptosporidium hominis Virulent Subtype IbA10G2
title_fullStr Genetic Recombination and Cryptosporidium hominis Virulent Subtype IbA10G2
title_full_unstemmed Genetic Recombination and Cryptosporidium hominis Virulent Subtype IbA10G2
title_short Genetic Recombination and Cryptosporidium hominis Virulent Subtype IbA10G2
title_sort genetic recombination and cryptosporidium hominis virulent subtype iba10g2
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810731/
https://www.ncbi.nlm.nih.gov/pubmed/24050210
http://dx.doi.org/10.3201/eid1910.121361
work_keys_str_mv AT lina geneticrecombinationandcryptosporidiumhominisvirulentsubtypeiba10g2
AT xiaolihua geneticrecombinationandcryptosporidiumhominisvirulentsubtypeiba10g2
AT camavitalianoa geneticrecombinationandcryptosporidiumhominisvirulentsubtypeiba10g2
AT ortegaynes geneticrecombinationandcryptosporidiumhominisvirulentsubtypeiba10g2
AT gilmanroberth geneticrecombinationandcryptosporidiumhominisvirulentsubtypeiba10g2
AT guomeijin geneticrecombinationandcryptosporidiumhominisvirulentsubtypeiba10g2
AT fengyaoyu geneticrecombinationandcryptosporidiumhominisvirulentsubtypeiba10g2