Emergence of Vaccine-derived Polioviruses, Democratic Republic of Congo, 2004–2011

Polioviruses isolated from 70 acute flaccid paralysis patients from the Democratic Republic of Congo (DRC) during 2004–2011 were characterized and found to be vaccine-derived type 2 polioviruses (VDPV2s). Partial genomic sequencing of the isolates revealed nucleotide sequence divergence of up to 3.5...

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Autores principales: Gumede, Nicksy, Lentsoane, Olivia, Burns, Cara C., Pallansch, Mark, de Gourville, Esther, Yogolelo, Riziki, Muyembe-Tamfum, Jean Jacques, Puren, Adrian, Schoub, Barry D., Venter, Marietjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810735/
https://www.ncbi.nlm.nih.gov/pubmed/24047933
http://dx.doi.org/10.3201/eid1910.130028
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author Gumede, Nicksy
Lentsoane, Olivia
Burns, Cara C.
Pallansch, Mark
de Gourville, Esther
Yogolelo, Riziki
Muyembe-Tamfum, Jean Jacques
Puren, Adrian
Schoub, Barry D.
Venter, Marietjie
author_facet Gumede, Nicksy
Lentsoane, Olivia
Burns, Cara C.
Pallansch, Mark
de Gourville, Esther
Yogolelo, Riziki
Muyembe-Tamfum, Jean Jacques
Puren, Adrian
Schoub, Barry D.
Venter, Marietjie
author_sort Gumede, Nicksy
collection PubMed
description Polioviruses isolated from 70 acute flaccid paralysis patients from the Democratic Republic of Congo (DRC) during 2004–2011 were characterized and found to be vaccine-derived type 2 polioviruses (VDPV2s). Partial genomic sequencing of the isolates revealed nucleotide sequence divergence of up to 3.5% in the viral protein 1 capsid region of the viral genome relative to the Sabin vaccine strain. Genetic analysis identified at least 7 circulating lineages localized to specific geographic regions. Multiple independent events of VDPV2 emergence occurred throughout DRC during this 7-year period. During 2010–2011, VDPV2 circulation in eastern DRC occurred in an area distinct from that of wild poliovirus circulation, whereas VDPV2 circulation in the southwestern part of DRC (in Kasai Occidental) occurred within the larger region of wild poliovirus circulation.
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spelling pubmed-38107352013-11-05 Emergence of Vaccine-derived Polioviruses, Democratic Republic of Congo, 2004–2011 Gumede, Nicksy Lentsoane, Olivia Burns, Cara C. Pallansch, Mark de Gourville, Esther Yogolelo, Riziki Muyembe-Tamfum, Jean Jacques Puren, Adrian Schoub, Barry D. Venter, Marietjie Emerg Infect Dis Research Polioviruses isolated from 70 acute flaccid paralysis patients from the Democratic Republic of Congo (DRC) during 2004–2011 were characterized and found to be vaccine-derived type 2 polioviruses (VDPV2s). Partial genomic sequencing of the isolates revealed nucleotide sequence divergence of up to 3.5% in the viral protein 1 capsid region of the viral genome relative to the Sabin vaccine strain. Genetic analysis identified at least 7 circulating lineages localized to specific geographic regions. Multiple independent events of VDPV2 emergence occurred throughout DRC during this 7-year period. During 2010–2011, VDPV2 circulation in eastern DRC occurred in an area distinct from that of wild poliovirus circulation, whereas VDPV2 circulation in the southwestern part of DRC (in Kasai Occidental) occurred within the larger region of wild poliovirus circulation. Centers for Disease Control and Prevention 2013-10 /pmc/articles/PMC3810735/ /pubmed/24047933 http://dx.doi.org/10.3201/eid1910.130028 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Gumede, Nicksy
Lentsoane, Olivia
Burns, Cara C.
Pallansch, Mark
de Gourville, Esther
Yogolelo, Riziki
Muyembe-Tamfum, Jean Jacques
Puren, Adrian
Schoub, Barry D.
Venter, Marietjie
Emergence of Vaccine-derived Polioviruses, Democratic Republic of Congo, 2004–2011
title Emergence of Vaccine-derived Polioviruses, Democratic Republic of Congo, 2004–2011
title_full Emergence of Vaccine-derived Polioviruses, Democratic Republic of Congo, 2004–2011
title_fullStr Emergence of Vaccine-derived Polioviruses, Democratic Republic of Congo, 2004–2011
title_full_unstemmed Emergence of Vaccine-derived Polioviruses, Democratic Republic of Congo, 2004–2011
title_short Emergence of Vaccine-derived Polioviruses, Democratic Republic of Congo, 2004–2011
title_sort emergence of vaccine-derived polioviruses, democratic republic of congo, 2004–2011
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810735/
https://www.ncbi.nlm.nih.gov/pubmed/24047933
http://dx.doi.org/10.3201/eid1910.130028
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