Reciprocal virulence and resistance polymorphism in the relationship between Toxoplasma gondii and the house mouse

Virulence in the ubiquitous intracellular protozoon Toxoplasma gondii for its natural intermediate host, the mouse, appears paradoxical from an evolutionary standpoint because death of the mouse before encystment interrupts the parasite life cycle. Virulent T. gondii strains secrete kinases and pseu...

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Autores principales: Lilue, Jingtao, Müller, Urs Benedikt, Steinfeldt, Tobias, Howard, Jonathan C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2013
Materias:
Genomics and Evolutionary Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810784/
https://www.ncbi.nlm.nih.gov/pubmed/24175088
http://dx.doi.org/10.7554/eLife.01298
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author Lilue, Jingtao
Müller, Urs Benedikt
Steinfeldt, Tobias
Howard, Jonathan C
author_facet Lilue, Jingtao
Müller, Urs Benedikt
Steinfeldt, Tobias
Howard, Jonathan C
author_sort Lilue, Jingtao
collection PubMed
description Virulence in the ubiquitous intracellular protozoon Toxoplasma gondii for its natural intermediate host, the mouse, appears paradoxical from an evolutionary standpoint because death of the mouse before encystment interrupts the parasite life cycle. Virulent T. gondii strains secrete kinases and pseudokinases that inactivate the immunity-related GTPases (IRG proteins) responsible for mouse resistance to avirulent strains. Such considerations stimulated a search for IRG alleles unknown in laboratory mice that might confer resistance to virulent strains of T. gondii. We report that the mouse IRG system shows extraordinary polymorphic complexity in the wild. We describe an IRG haplotype from a wild-derived mouse strain that confers resistance against virulent parasites by interference with the virulent kinase complex. In such hosts virulent strains can encyst, hinting at an explanation for the evolution of virulence polymorphism in T. gondii. DOI: http://dx.doi.org/10.7554/eLife.01298.001
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spelling pubmed-38107842013-10-30 Reciprocal virulence and resistance polymorphism in the relationship between Toxoplasma gondii and the house mouse Lilue, Jingtao Müller, Urs Benedikt Steinfeldt, Tobias Howard, Jonathan C eLife Genomics and Evolutionary Biology Virulence in the ubiquitous intracellular protozoon Toxoplasma gondii for its natural intermediate host, the mouse, appears paradoxical from an evolutionary standpoint because death of the mouse before encystment interrupts the parasite life cycle. Virulent T. gondii strains secrete kinases and pseudokinases that inactivate the immunity-related GTPases (IRG proteins) responsible for mouse resistance to avirulent strains. Such considerations stimulated a search for IRG alleles unknown in laboratory mice that might confer resistance to virulent strains of T. gondii. We report that the mouse IRG system shows extraordinary polymorphic complexity in the wild. We describe an IRG haplotype from a wild-derived mouse strain that confers resistance against virulent parasites by interference with the virulent kinase complex. In such hosts virulent strains can encyst, hinting at an explanation for the evolution of virulence polymorphism in T. gondii. DOI: http://dx.doi.org/10.7554/eLife.01298.001 eLife Sciences Publications, Ltd 2013-10-29 /pmc/articles/PMC3810784/ /pubmed/24175088 http://dx.doi.org/10.7554/eLife.01298 Text en Copyright © 2013, Lilue et al http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Genomics and Evolutionary Biology
Lilue, Jingtao
Müller, Urs Benedikt
Steinfeldt, Tobias
Howard, Jonathan C
Reciprocal virulence and resistance polymorphism in the relationship between Toxoplasma gondii and the house mouse
title Reciprocal virulence and resistance polymorphism in the relationship between Toxoplasma gondii and the house mouse
title_full Reciprocal virulence and resistance polymorphism in the relationship between Toxoplasma gondii and the house mouse
title_fullStr Reciprocal virulence and resistance polymorphism in the relationship between Toxoplasma gondii and the house mouse
title_full_unstemmed Reciprocal virulence and resistance polymorphism in the relationship between Toxoplasma gondii and the house mouse
title_short Reciprocal virulence and resistance polymorphism in the relationship between Toxoplasma gondii and the house mouse
title_sort reciprocal virulence and resistance polymorphism in the relationship between toxoplasma gondii and the house mouse
topic Genomics and Evolutionary Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810784/
https://www.ncbi.nlm.nih.gov/pubmed/24175088
http://dx.doi.org/10.7554/eLife.01298
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