Cargando…

The 5-aminosalicylic acid antineoplastic effect in the intestine is mediated by PPARγ

Epidemiological evidences suggested that 5-aminosalicylic acid (5-ASA) therapy may prevent the development of colorectal cancer in inflammatory bowel disease patients. Our aim is to investigate whether peroxisome proliferator-activated receptor-γ (PPARγ) mediates the antineoplastic effects of 5-ASA....

Descripción completa

Detalles Bibliográficos
Autores principales:	Rousseaux, Christel, El-Jamal, Noura, Fumery, Mathurin, Dubuquoy, Caroline, Romano, Olivier, Chatelain, Denis, Langlois, Audrey, Bertin, Benjamin, Buob, David, Colombel, Jean Frederic, Cortot, Antoine, Desreumaux, Pierre, Dubuquoy, Laurent
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2013
Materias:	Original Manuscript
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810841/ https://www.ncbi.nlm.nih.gov/pubmed/23843037 http://dx.doi.org/10.1093/carcin/bgt245

Ejemplares similares

Peroxisome proliferator‐activated receptor gamma (PPARγ) regulates lactase expression and activity in the gut
por: Fumery, Mathurin, et al.
Publicado: (2017)

Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator–activated receptor-γ
por: Rousseaux, Christel, et al.
Publicado: (2005)

GED-0507 attenuates lung fibrosis by counteracting myofibroblast transdifferentiation in vivo and in vitro
por: Speca, Silvia, et al.
Publicado: (2021)

Mesenteric fat as a source of C reactive protein and as a target for bacterial translocation in Crohn's disease
por: Peyrin-Biroulet, Laurent, et al.
Publicado: (2011)

Colonic Inflammation in Mice Is Improved by Cigarette Smoke through iNKT Cells Recruitment
por: Montbarbon, Muriel, et al.
Publicado: (2013)

The Expression of the Short Isoform of Thymic Stromal Lymphopoietin in the Colon Is Regulated by the Nuclear Receptor Peroxisome Proliferator Activated Receptor-Gamma and Is Impaired during Ulcerative Colitis
por: Martin Mena, Anthony, et al.
Publicado: (2017)

Attenuation of Colon Inflammation through Activators of the Retinoid X Receptor (Rxr)/Peroxisome Proliferator–Activated Receptor γ (Pparγ) Heterodimer: A Basis for New Therapeutic Strategies
por: Desreumaux, Pierre, et al.
Publicado: (2001)

The schistosome glutathione S-transferase P28GST, a unique helminth protein, prevents intestinal inflammation in experimental colitis through a Th2-type response with mucosal eosinophils
por: Driss, V, et al.
Publicado: (2016)

Role of glycogen synthase kinase-3β and PPAR-γ on epithelial-to-mesenchymal transition in DSS-induced colorectal fibrosis
por: Di Gregorio, Jacopo, et al.
Publicado: (2017)

Treatment with P28GST, a schistosome-derived enzyme, after acute colitis induction in mice: Decrease of intestinal inflammation associated with a down regulation of Th1/Th17 responses
por: Sarazin, Aurore, et al.
Publicado: (2018)

Antineoplastic effects of rosiglitazone and PPARγ transactivation in neuroblastoma cells
por: Cellai, I, et al.
Publicado: (2006)

High carriage of adherent invasive E. coli in wildlife and healthy individuals
por: Rahmouni, Oumaïra, et al.
Publicado: (2018)

PPAR-γ Agonists As Antineoplastic Agents in Cancers with Dysregulated IGF Axis
por: Vella, Veronica, et al.
Publicado: (2017)

Peroxisome Proliferator-Activated Receptors in HCV-Related Infection
por: Dharancy, Sébastien, et al.
Publicado: (2009)

Peroxisome Proliferator-Activated Receptors in HBV-Related Infection
por: Dubuquoy, Laurent, et al.
Publicado: (2009)

Delivery of a mucin domain enriched in cysteine residues strengthens the intestinal mucous barrier
por: Gouyer, Valérie, et al.
Publicado: (2015)

5-Aminosalicylic Acid Ameliorates Colitis and Checks Dysbiotic Escherichia coli Expansion by Activating PPAR-γ Signaling in the Intestinal Epithelium
por: Cevallos, Stephanie A., et al.
Publicado: (2021)

Contribution of the Gut Microbiota in P28GST-Mediated Anti-Inflammatory Effects: Experimental and Clinical Insights
por: Foligné, Benoît, et al.
Publicado: (2019)

5-aminosalicylic acid improves lipid profile in mice fed a high-fat cholesterol diet through its dual effects on intestinal PPARγ and PPARα
por: Wang, Zheng, et al.
Publicado: (2018)

Saccharomyces cerevisiae prevents postoperative recurrence of Crohn's disease modeled by ileocecal resection in HLA-B27 transgenic rats
por: Valibouze, Caroline, et al.
Publicado: (2023)

Retraction: 5-aminosalicylic acid improves lipid profile in mice fed a high-fat cholesterol diet through its dual effects on intestinal PPARγ and PPARα
por: Wang, Zheng, et al.
Publicado: (2018)

Neoboutonia melleri var velutina Prain: in vitro and in vivo hepatoprotective effects of the aqueous stem bark extract on acute hepatitis models
por: Endougou Effa, Anne Marie, et al.
Publicado: (2018)

Aluminum Ingestion Promotes Colorectal Hypersensitivity in Rodents
por: Esquerre, Nicolas, et al.
Publicado: (2018)

MicroRNAs, Tristetraprolin Family Members and HuR: A Complex Interplay Controlling Cancer-Related Processes
por: Sobolewski, Cyril, et al.
Publicado: (2022)

Starch-based NP act as antigen delivery systems without immunomodulating effect
por: Fasquelle, François, et al.
Publicado: (2022)

Para-Aminosalicylic Acid: Pas
Publicado: (1950)

Epstein‐Barr Virus‐related mucocutaneous ulcer lymphoma associated with Crohn's disease, treated with monoclonal antibody anti‐CD30
por: Montes, Lydia, et al.
Publicado: (2020)

Starch nanoparticles improve curcumin-induced production of anti-inflammatory cytokines in intestinal epithelial cells
por: Salah, Norhane, et al.
Publicado: (2022)

Peroxisome Proliferator-Activated Receptors (PPARs) as Potential Inducers of Antineoplastic Effects in CNS Tumors
por: Tatenhorst, Lars, et al.
Publicado: (2008)

Para-Aminosalicylic Acid in Pulmonary Tuberculosis
por: Horne, Norman W.
Publicado: (1949)

p-Aminosalicylic Acid (P.A.S.)
por: Spring, F. S.
Publicado: (1949)

Aminosalicylates and COVID-19: Facts or Coincidences?
por: Magro, Fernando, et al.
Publicado: (2021)

Safety of P28GST, a Protein Derived from a Schistosome Helminth Parasite, in Patients with Crohn’s Disease: A Pilot Study (ACROHNEM)
por: Capron, Monique, et al.
Publicado: (2019)

Corrigendum: Polymorphisms in the Mannose-Binding Lectin Gene are Associated with Defective Mannose-Binding Lectin Functional Activity in Crohn’s Disease Patients
por: Choteau, Laura, et al.
Publicado: (2016)

Polymorphisms in the Mannose-Binding Lectin Gene are Associated with Defective Mannose-Binding Lectin Functional Activity in Crohn’s Disease Patients
por: Choteau, Laura, et al.
Publicado: (2016)

Patients’ Plasma Activity of Heparin, low-Molecular-Weight Heparin or no Anticoagulants on Urine Based DOAC Test Strips
por: Harenberg, Job, et al.
Publicado: (2022)

PPARγ in Neuroblastoma
por: Peri, Alessandro, et al.
Publicado: (2008)

Dysregulation of the Amniotic PPARγ Pathway by Phthalates: Modulation of the Anti-Inflammatory Activity of PPARγ in Human Fetal Membranes
por: Antoine, Audrey, et al.
Publicado: (2022)

Emerging PPARγ-Independent Role of PPARγ Ligands in Lung Diseases
por: Kulkarni, Ajit A., et al.
Publicado: (2012)

Self-Assembling Polymers with p-Aminosalicylate Anions Supported by Encapsulation of p-Aminosalicylate for the Improvement of Drug Content and Release Efficiency
por: Keihankhadiv, Shadi, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_0g8tf1keo8qluhff40m4njn2mr