R292K Substitution and Drug Susceptibility of Influenza A(H7N9) Viruses

Neuraminidase inhibitors are the only licensed antiviral medications available to treat avian influenza A(H7N9) virus infections in humans. According to a neuraminidase inhibition assay, an R292K substitution reduced antiviral efficacy of inhibitors, especially oseltamivir, and decreased viral fitne...

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Detalles Bibliográficos
Autores principales: Sleeman, Katrina, Guo, Zhu, Barnes, John, Shaw, Michael, Stevens, James, Gubareva, Larisa V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2013
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810934/
https://www.ncbi.nlm.nih.gov/pubmed/23965618
http://dx.doi.org/10.3201/eid1909.130724
Descripción
Sumario:Neuraminidase inhibitors are the only licensed antiviral medications available to treat avian influenza A(H7N9) virus infections in humans. According to a neuraminidase inhibition assay, an R292K substitution reduced antiviral efficacy of inhibitors, especially oseltamivir, and decreased viral fitness in cell culture. Monitoring emergence of R292K-carrying viruses using a pH-modified neuraminidase inhibition assay should be considered.

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