R292K Substitution and Drug Susceptibility of Influenza A(H7N9) Viruses

Neuraminidase inhibitors are the only licensed antiviral medications available to treat avian influenza A(H7N9) virus infections in humans. According to a neuraminidase inhibition assay, an R292K substitution reduced antiviral efficacy of inhibitors, especially oseltamivir, and decreased viral fitne...

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Autores principales: Sleeman, Katrina, Guo, Zhu, Barnes, John, Shaw, Michael, Stevens, James, Gubareva, Larisa V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2013
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810934/
https://www.ncbi.nlm.nih.gov/pubmed/23965618
http://dx.doi.org/10.3201/eid1909.130724
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author Sleeman, Katrina
Guo, Zhu
Barnes, John
Shaw, Michael
Stevens, James
Gubareva, Larisa V.
author_facet Sleeman, Katrina
Guo, Zhu
Barnes, John
Shaw, Michael
Stevens, James
Gubareva, Larisa V.
author_sort Sleeman, Katrina
collection PubMed
description Neuraminidase inhibitors are the only licensed antiviral medications available to treat avian influenza A(H7N9) virus infections in humans. According to a neuraminidase inhibition assay, an R292K substitution reduced antiviral efficacy of inhibitors, especially oseltamivir, and decreased viral fitness in cell culture. Monitoring emergence of R292K-carrying viruses using a pH-modified neuraminidase inhibition assay should be considered.
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spelling pubmed-38109342013-11-05 R292K Substitution and Drug Susceptibility of Influenza A(H7N9) Viruses Sleeman, Katrina Guo, Zhu Barnes, John Shaw, Michael Stevens, James Gubareva, Larisa V. Emerg Infect Dis Dispatch Neuraminidase inhibitors are the only licensed antiviral medications available to treat avian influenza A(H7N9) virus infections in humans. According to a neuraminidase inhibition assay, an R292K substitution reduced antiviral efficacy of inhibitors, especially oseltamivir, and decreased viral fitness in cell culture. Monitoring emergence of R292K-carrying viruses using a pH-modified neuraminidase inhibition assay should be considered. Centers for Disease Control and Prevention 2013-09 /pmc/articles/PMC3810934/ /pubmed/23965618 http://dx.doi.org/10.3201/eid1909.130724 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Sleeman, Katrina
Guo, Zhu
Barnes, John
Shaw, Michael
Stevens, James
Gubareva, Larisa V.
R292K Substitution and Drug Susceptibility of Influenza A(H7N9) Viruses
title R292K Substitution and Drug Susceptibility of Influenza A(H7N9) Viruses
title_full R292K Substitution and Drug Susceptibility of Influenza A(H7N9) Viruses
title_fullStr R292K Substitution and Drug Susceptibility of Influenza A(H7N9) Viruses
title_full_unstemmed R292K Substitution and Drug Susceptibility of Influenza A(H7N9) Viruses
title_short R292K Substitution and Drug Susceptibility of Influenza A(H7N9) Viruses
title_sort r292k substitution and drug susceptibility of influenza a(h7n9) viruses
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810934/
https://www.ncbi.nlm.nih.gov/pubmed/23965618
http://dx.doi.org/10.3201/eid1909.130724
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