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Animal models and high field imaging and spectroscopy

A plethora of magnetic resonance (MR) techniques developed in the last two decades provide unique and noninvasive measurement capabilities for studies of basic brain function and brain diseases in humans. Animal model experiments have been an indispensible part of this development. MR imaging and sp...

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Autores principales: Öz, Gülin, Tkáč, Ivan, Uğurbil, Kamil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Les Laboratoires Servier 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811099/
https://www.ncbi.nlm.nih.gov/pubmed/24174899
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author Öz, Gülin
Tkáč, Ivan
Uğurbil, Kamil
author_facet Öz, Gülin
Tkáč, Ivan
Uğurbil, Kamil
author_sort Öz, Gülin
collection PubMed
description A plethora of magnetic resonance (MR) techniques developed in the last two decades provide unique and noninvasive measurement capabilities for studies of basic brain function and brain diseases in humans. Animal model experiments have been an indispensible part of this development. MR imaging and spectroscopy measurements have been employed in animal models, either by themselves or in combination with complementary and often invasive techniques, to enlighten us about the information content of such MR methods and/or verify observations made in the human brain. They have also been employed, with or independently of human efforts, to examine mechanisms underlying pathological developments in the brain, exploiting the wealth of animal models available for such studies. In this endeavor, the desire to push for ever-higher spatial and/or spectral resolution, better signal-to-noise ratio, and unique image contrast has inevitably led to the introduction of increasingly higher magnetic fields. As a result, today, animal model studies are starting to be conducted at magnetic fields ranging from ~ 11 to 17 Tesla, significantly enhancing the armamentarium of tools available for the probing brain function and brain pathologies.
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spelling pubmed-38110992013-10-30 Animal models and high field imaging and spectroscopy Öz, Gülin Tkáč, Ivan Uğurbil, Kamil Dialogues Clin Neurosci Translational Research A plethora of magnetic resonance (MR) techniques developed in the last two decades provide unique and noninvasive measurement capabilities for studies of basic brain function and brain diseases in humans. Animal model experiments have been an indispensible part of this development. MR imaging and spectroscopy measurements have been employed in animal models, either by themselves or in combination with complementary and often invasive techniques, to enlighten us about the information content of such MR methods and/or verify observations made in the human brain. They have also been employed, with or independently of human efforts, to examine mechanisms underlying pathological developments in the brain, exploiting the wealth of animal models available for such studies. In this endeavor, the desire to push for ever-higher spatial and/or spectral resolution, better signal-to-noise ratio, and unique image contrast has inevitably led to the introduction of increasingly higher magnetic fields. As a result, today, animal model studies are starting to be conducted at magnetic fields ranging from ~ 11 to 17 Tesla, significantly enhancing the armamentarium of tools available for the probing brain function and brain pathologies. Les Laboratoires Servier 2013-09 /pmc/articles/PMC3811099/ /pubmed/24174899 Text en Copyright: © 2013 Institut la Conférence Hippocrate - Servier Research Group http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Translational Research
Öz, Gülin
Tkáč, Ivan
Uğurbil, Kamil
Animal models and high field imaging and spectroscopy
title Animal models and high field imaging and spectroscopy
title_full Animal models and high field imaging and spectroscopy
title_fullStr Animal models and high field imaging and spectroscopy
title_full_unstemmed Animal models and high field imaging and spectroscopy
title_short Animal models and high field imaging and spectroscopy
title_sort animal models and high field imaging and spectroscopy
topic Translational Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811099/
https://www.ncbi.nlm.nih.gov/pubmed/24174899
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