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Cyclic AMP Effectors in African Trypanosomes Revealed by Genome-Scale RNA Interference Library Screening for Resistance to the Phosphodiesterase Inhibitor CpdA

One of the most promising new targets for trypanocidal drugs to emerge in recent years is the cyclic AMP (cAMP) phosphodiesterase (PDE) activity encoded by TbrPDEB1 and TbrPDEB2. These genes were genetically confirmed as essential, and a high-affinity inhibitor, CpdA, displays potent antitrypanosoma...

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Detalles Bibliográficos
Autores principales:	Gould, Matthew K., Bachmaier, Sabine, Ali, Juma A. M., Alsford, Sam, Tagoe, Daniel N. A., Munday, Jane C., Schnaufer, Achim C., Horn, David, Boshart, Michael, de Koning, Harry P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2013
Materias:	Mechanisms of Resistance
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811416/ https://www.ncbi.nlm.nih.gov/pubmed/23877697 http://dx.doi.org/10.1128/AAC.00508-13

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