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Comparison of the clinical outcomes of day 4 and 5 embryo transfer cycles

OBJECTIVE: The majority of embryo transfers (ETs) to date have been performed on day 3 to reduce the potential risk of developmental arrest of in vitro cultured embryos before ET. Development of sequential media has significantly improved culture conditions and allowed blastocyst transfer on day 5....

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Autores principales: Lee, Sun-Hee, Lee, Hyoung-Song, Lim, Chun Kyu, Park, Yong-Seog, Yang, Kwang Moon, Park, Dong Wook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Reproductive Medicine 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811723/
https://www.ncbi.nlm.nih.gov/pubmed/24179869
http://dx.doi.org/10.5653/cerm.2013.40.3.122
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author Lee, Sun-Hee
Lee, Hyoung-Song
Lim, Chun Kyu
Park, Yong-Seog
Yang, Kwang Moon
Park, Dong Wook
author_facet Lee, Sun-Hee
Lee, Hyoung-Song
Lim, Chun Kyu
Park, Yong-Seog
Yang, Kwang Moon
Park, Dong Wook
author_sort Lee, Sun-Hee
collection PubMed
description OBJECTIVE: The majority of embryo transfers (ETs) to date have been performed on day 3 to reduce the potential risk of developmental arrest of in vitro cultured embryos before ET. Development of sequential media has significantly improved culture conditions and allowed blastocyst transfer on day 5. While day 5 ET provides higher clinical pregnancy outcomes with reduced risks of multiple pregnancies, it still has potential risks of developmental arrest of IVF embryos. The aim of this study was to evaluate the clinical outcomes of day 4 ETs and compare the efficacy of day 4 ET with day 5 ET. METHODS: From 2006 to 2009, a total of 747 fresh IVF-ET cycles were retrospectively analyzed (day 4, n=440 or and day 5, n=307). The cycles with any genetic factors were excluded. The rates of matured oocytes, fertilization, good embryos, and clinical pregnancy of the two groups were compared. The chi-square test and t-test were used for statistical analysis. RESULTS: There were no significant differences between the two groups with respect to the mean age of the females and rates of matured oocytes. The pregnancy outcomes of day 4 ET (40.7%) were similar to those of day 5 ET (44.6%). The implantation rate of day 5 ET (24.2%) was significantly higher than that of day 4 ET (18.4%) (p=0.003). CONCLUSION: Day 4 ET can be chosen to avoid ET cancellation in day 5 ET resulting from suboptimal circumstances in the IVF laboratory, but the decremented quality of embryos for transfer and the decreased pregnancy rate must be taken into consideration.
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spelling pubmed-38117232013-10-31 Comparison of the clinical outcomes of day 4 and 5 embryo transfer cycles Lee, Sun-Hee Lee, Hyoung-Song Lim, Chun Kyu Park, Yong-Seog Yang, Kwang Moon Park, Dong Wook Clin Exp Reprod Med Original Article OBJECTIVE: The majority of embryo transfers (ETs) to date have been performed on day 3 to reduce the potential risk of developmental arrest of in vitro cultured embryos before ET. Development of sequential media has significantly improved culture conditions and allowed blastocyst transfer on day 5. While day 5 ET provides higher clinical pregnancy outcomes with reduced risks of multiple pregnancies, it still has potential risks of developmental arrest of IVF embryos. The aim of this study was to evaluate the clinical outcomes of day 4 ETs and compare the efficacy of day 4 ET with day 5 ET. METHODS: From 2006 to 2009, a total of 747 fresh IVF-ET cycles were retrospectively analyzed (day 4, n=440 or and day 5, n=307). The cycles with any genetic factors were excluded. The rates of matured oocytes, fertilization, good embryos, and clinical pregnancy of the two groups were compared. The chi-square test and t-test were used for statistical analysis. RESULTS: There were no significant differences between the two groups with respect to the mean age of the females and rates of matured oocytes. The pregnancy outcomes of day 4 ET (40.7%) were similar to those of day 5 ET (44.6%). The implantation rate of day 5 ET (24.2%) was significantly higher than that of day 4 ET (18.4%) (p=0.003). CONCLUSION: Day 4 ET can be chosen to avoid ET cancellation in day 5 ET resulting from suboptimal circumstances in the IVF laboratory, but the decremented quality of embryos for transfer and the decreased pregnancy rate must be taken into consideration. The Korean Society for Reproductive Medicine 2013-09 2013-09-30 /pmc/articles/PMC3811723/ /pubmed/24179869 http://dx.doi.org/10.5653/cerm.2013.40.3.122 Text en Copyright © 2013. The Korean Society for Reproductive Medicine http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lee, Sun-Hee
Lee, Hyoung-Song
Lim, Chun Kyu
Park, Yong-Seog
Yang, Kwang Moon
Park, Dong Wook
Comparison of the clinical outcomes of day 4 and 5 embryo transfer cycles
title Comparison of the clinical outcomes of day 4 and 5 embryo transfer cycles
title_full Comparison of the clinical outcomes of day 4 and 5 embryo transfer cycles
title_fullStr Comparison of the clinical outcomes of day 4 and 5 embryo transfer cycles
title_full_unstemmed Comparison of the clinical outcomes of day 4 and 5 embryo transfer cycles
title_short Comparison of the clinical outcomes of day 4 and 5 embryo transfer cycles
title_sort comparison of the clinical outcomes of day 4 and 5 embryo transfer cycles
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811723/
https://www.ncbi.nlm.nih.gov/pubmed/24179869
http://dx.doi.org/10.5653/cerm.2013.40.3.122
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