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Neuroprotective effects of tanshinone I from Danshen extract in a mouse model of hypoxia-ischemia
Hypoxia-ischemia leads to serious neuronal damage in some brain regions and is a strong risk factor for stroke. The aim of this study was to investigate the neuroprotective effect of tanshinone I (TsI) derived from Danshen (Radix Salvia miltiorrhiza root extract) against neuronal damage using a mous...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Association of Anatomists
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811852/ https://www.ncbi.nlm.nih.gov/pubmed/24179693 http://dx.doi.org/10.5115/acb.2013.46.3.183 |
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author | Lee, Jae-Chul Park, Joon Ha Park, Ok Kyu Kim, In Hye Yan, Bing Chun Ahn, Ji Hyeon Kwon, Seung-Hae Choi, Jung Hoon Kim, Jong-Dai Won, Moo-Ho |
author_facet | Lee, Jae-Chul Park, Joon Ha Park, Ok Kyu Kim, In Hye Yan, Bing Chun Ahn, Ji Hyeon Kwon, Seung-Hae Choi, Jung Hoon Kim, Jong-Dai Won, Moo-Ho |
author_sort | Lee, Jae-Chul |
collection | PubMed |
description | Hypoxia-ischemia leads to serious neuronal damage in some brain regions and is a strong risk factor for stroke. The aim of this study was to investigate the neuroprotective effect of tanshinone I (TsI) derived from Danshen (Radix Salvia miltiorrhiza root extract) against neuronal damage using a mouse model of cerebral hypoxia-ischemia. Brain infarction and neuronal damage were examined using 2,3,5-triphenyltetrazolium chloride (TTC) staining, hematoxylin and eosin histochemistry, and Fluoro-Jade B histofluorescence. Pre-treatment with TsI (10 mg/kg) was associated with a significant reduction in infarct volume 1 day after hypoxia-ischemia was induced. In addition, TsI protected against hypoxia-ischemia-induced neuronal death in the ipsilateral region. Our present findings suggest that TsI has strong potential for neuroprotection against hypoxic-ischemic damage. These results may be used in research into new anti-stroke medications. |
format | Online Article Text |
id | pubmed-3811852 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Korean Association of Anatomists |
record_format | MEDLINE/PubMed |
spelling | pubmed-38118522013-10-31 Neuroprotective effects of tanshinone I from Danshen extract in a mouse model of hypoxia-ischemia Lee, Jae-Chul Park, Joon Ha Park, Ok Kyu Kim, In Hye Yan, Bing Chun Ahn, Ji Hyeon Kwon, Seung-Hae Choi, Jung Hoon Kim, Jong-Dai Won, Moo-Ho Anat Cell Biol Original Article Hypoxia-ischemia leads to serious neuronal damage in some brain regions and is a strong risk factor for stroke. The aim of this study was to investigate the neuroprotective effect of tanshinone I (TsI) derived from Danshen (Radix Salvia miltiorrhiza root extract) against neuronal damage using a mouse model of cerebral hypoxia-ischemia. Brain infarction and neuronal damage were examined using 2,3,5-triphenyltetrazolium chloride (TTC) staining, hematoxylin and eosin histochemistry, and Fluoro-Jade B histofluorescence. Pre-treatment with TsI (10 mg/kg) was associated with a significant reduction in infarct volume 1 day after hypoxia-ischemia was induced. In addition, TsI protected against hypoxia-ischemia-induced neuronal death in the ipsilateral region. Our present findings suggest that TsI has strong potential for neuroprotection against hypoxic-ischemic damage. These results may be used in research into new anti-stroke medications. Korean Association of Anatomists 2013-09 2013-09-30 /pmc/articles/PMC3811852/ /pubmed/24179693 http://dx.doi.org/10.5115/acb.2013.46.3.183 Text en Copyright © 2013. Anatomy & Cell Biology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Lee, Jae-Chul Park, Joon Ha Park, Ok Kyu Kim, In Hye Yan, Bing Chun Ahn, Ji Hyeon Kwon, Seung-Hae Choi, Jung Hoon Kim, Jong-Dai Won, Moo-Ho Neuroprotective effects of tanshinone I from Danshen extract in a mouse model of hypoxia-ischemia |
title | Neuroprotective effects of tanshinone I from Danshen extract in a mouse model of hypoxia-ischemia |
title_full | Neuroprotective effects of tanshinone I from Danshen extract in a mouse model of hypoxia-ischemia |
title_fullStr | Neuroprotective effects of tanshinone I from Danshen extract in a mouse model of hypoxia-ischemia |
title_full_unstemmed | Neuroprotective effects of tanshinone I from Danshen extract in a mouse model of hypoxia-ischemia |
title_short | Neuroprotective effects of tanshinone I from Danshen extract in a mouse model of hypoxia-ischemia |
title_sort | neuroprotective effects of tanshinone i from danshen extract in a mouse model of hypoxia-ischemia |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811852/ https://www.ncbi.nlm.nih.gov/pubmed/24179693 http://dx.doi.org/10.5115/acb.2013.46.3.183 |
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