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Perforin and Granzyme B Have Separate and Distinct Roles during Atherosclerotic Plaque Development in Apolipoprotein E Knockout Mice

The granzyme B/perforincytotoxic pathway is a well established mechanism of initiating target cell apoptosis. Previous studies have suggested a role for the granzyme B/perforin cytotoxic pathway in vulnerable atherosclerotic plaque formation. In the present study, granzyme B deficiency resulted in r...

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Detalles Bibliográficos
Autores principales:	Hiebert, Paul R., Boivin, Wendy A., Zhao, Hongyan, McManus, Bruce M., Granville, David J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811993/ https://www.ncbi.nlm.nih.gov/pubmed/24205352 http://dx.doi.org/10.1371/journal.pone.0078939

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