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Protein Trafficking through the Endosomal System Prepares Intracellular Parasites for a Home Invasion

Toxoplasma (toxoplasmosis) and Plasmodium (malaria) use unique secretory organelles for migration, cell invasion, manipulation of host cell functions, and cell egress. In particular, the apical secretory micronemes and rhoptries of apicomplexan parasites are essential for successful host infection....

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Autores principales: Tomavo, Stanislas, Slomianny, Christian, Meissner, Markus, Carruthers, Vern B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812028/
https://www.ncbi.nlm.nih.gov/pubmed/24204248
http://dx.doi.org/10.1371/journal.ppat.1003629
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author Tomavo, Stanislas
Slomianny, Christian
Meissner, Markus
Carruthers, Vern B.
author_facet Tomavo, Stanislas
Slomianny, Christian
Meissner, Markus
Carruthers, Vern B.
author_sort Tomavo, Stanislas
collection PubMed
description Toxoplasma (toxoplasmosis) and Plasmodium (malaria) use unique secretory organelles for migration, cell invasion, manipulation of host cell functions, and cell egress. In particular, the apical secretory micronemes and rhoptries of apicomplexan parasites are essential for successful host infection. New findings reveal that the contents of these organelles, which are transported through the endoplasmic reticulum (ER) and Golgi, also require the parasite endosome-like system to access their respective organelles. In this review, we discuss recent findings that demonstrate that these parasites reduced their endosomal system and modified classical regulators of this pathway for the biogenesis of apical organelles.
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spelling pubmed-38120282013-11-07 Protein Trafficking through the Endosomal System Prepares Intracellular Parasites for a Home Invasion Tomavo, Stanislas Slomianny, Christian Meissner, Markus Carruthers, Vern B. PLoS Pathog Review Toxoplasma (toxoplasmosis) and Plasmodium (malaria) use unique secretory organelles for migration, cell invasion, manipulation of host cell functions, and cell egress. In particular, the apical secretory micronemes and rhoptries of apicomplexan parasites are essential for successful host infection. New findings reveal that the contents of these organelles, which are transported through the endoplasmic reticulum (ER) and Golgi, also require the parasite endosome-like system to access their respective organelles. In this review, we discuss recent findings that demonstrate that these parasites reduced their endosomal system and modified classical regulators of this pathway for the biogenesis of apical organelles. Public Library of Science 2013-10-24 /pmc/articles/PMC3812028/ /pubmed/24204248 http://dx.doi.org/10.1371/journal.ppat.1003629 Text en © 2013 Tomavo et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Review
Tomavo, Stanislas
Slomianny, Christian
Meissner, Markus
Carruthers, Vern B.
Protein Trafficking through the Endosomal System Prepares Intracellular Parasites for a Home Invasion
title Protein Trafficking through the Endosomal System Prepares Intracellular Parasites for a Home Invasion
title_full Protein Trafficking through the Endosomal System Prepares Intracellular Parasites for a Home Invasion
title_fullStr Protein Trafficking through the Endosomal System Prepares Intracellular Parasites for a Home Invasion
title_full_unstemmed Protein Trafficking through the Endosomal System Prepares Intracellular Parasites for a Home Invasion
title_short Protein Trafficking through the Endosomal System Prepares Intracellular Parasites for a Home Invasion
title_sort protein trafficking through the endosomal system prepares intracellular parasites for a home invasion
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812028/
https://www.ncbi.nlm.nih.gov/pubmed/24204248
http://dx.doi.org/10.1371/journal.ppat.1003629
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