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Protein Trafficking through the Endosomal System Prepares Intracellular Parasites for a Home Invasion
Toxoplasma (toxoplasmosis) and Plasmodium (malaria) use unique secretory organelles for migration, cell invasion, manipulation of host cell functions, and cell egress. In particular, the apical secretory micronemes and rhoptries of apicomplexan parasites are essential for successful host infection....
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812028/ https://www.ncbi.nlm.nih.gov/pubmed/24204248 http://dx.doi.org/10.1371/journal.ppat.1003629 |
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author | Tomavo, Stanislas Slomianny, Christian Meissner, Markus Carruthers, Vern B. |
author_facet | Tomavo, Stanislas Slomianny, Christian Meissner, Markus Carruthers, Vern B. |
author_sort | Tomavo, Stanislas |
collection | PubMed |
description | Toxoplasma (toxoplasmosis) and Plasmodium (malaria) use unique secretory organelles for migration, cell invasion, manipulation of host cell functions, and cell egress. In particular, the apical secretory micronemes and rhoptries of apicomplexan parasites are essential for successful host infection. New findings reveal that the contents of these organelles, which are transported through the endoplasmic reticulum (ER) and Golgi, also require the parasite endosome-like system to access their respective organelles. In this review, we discuss recent findings that demonstrate that these parasites reduced their endosomal system and modified classical regulators of this pathway for the biogenesis of apical organelles. |
format | Online Article Text |
id | pubmed-3812028 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-38120282013-11-07 Protein Trafficking through the Endosomal System Prepares Intracellular Parasites for a Home Invasion Tomavo, Stanislas Slomianny, Christian Meissner, Markus Carruthers, Vern B. PLoS Pathog Review Toxoplasma (toxoplasmosis) and Plasmodium (malaria) use unique secretory organelles for migration, cell invasion, manipulation of host cell functions, and cell egress. In particular, the apical secretory micronemes and rhoptries of apicomplexan parasites are essential for successful host infection. New findings reveal that the contents of these organelles, which are transported through the endoplasmic reticulum (ER) and Golgi, also require the parasite endosome-like system to access their respective organelles. In this review, we discuss recent findings that demonstrate that these parasites reduced their endosomal system and modified classical regulators of this pathway for the biogenesis of apical organelles. Public Library of Science 2013-10-24 /pmc/articles/PMC3812028/ /pubmed/24204248 http://dx.doi.org/10.1371/journal.ppat.1003629 Text en © 2013 Tomavo et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Review Tomavo, Stanislas Slomianny, Christian Meissner, Markus Carruthers, Vern B. Protein Trafficking through the Endosomal System Prepares Intracellular Parasites for a Home Invasion |
title | Protein Trafficking through the Endosomal System Prepares Intracellular Parasites for a Home Invasion |
title_full | Protein Trafficking through the Endosomal System Prepares Intracellular Parasites for a Home Invasion |
title_fullStr | Protein Trafficking through the Endosomal System Prepares Intracellular Parasites for a Home Invasion |
title_full_unstemmed | Protein Trafficking through the Endosomal System Prepares Intracellular Parasites for a Home Invasion |
title_short | Protein Trafficking through the Endosomal System Prepares Intracellular Parasites for a Home Invasion |
title_sort | protein trafficking through the endosomal system prepares intracellular parasites for a home invasion |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812028/ https://www.ncbi.nlm.nih.gov/pubmed/24204248 http://dx.doi.org/10.1371/journal.ppat.1003629 |
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