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Expression of the Mismatch Repair Gene hMLH1 Is Enhanced in Non-Small Cell Lung Cancer with EGFR Mutations

Mismatch repair (MMR) plays a pivotal role in keeping the genome stable. MMR dysfunction can lead to carcinogenesis by gene mutation accumulation. HMSH2 and hMLH1 are two key components of MMR. High or low expression of them often mark the status of MMR function. Mutations (EGFR, KRAS, etc) are comm...

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Detalles Bibliográficos
Autores principales:	Li, Mei, Zhang, Qiuping, Liu, Lina, Lu, Weipeng, Wei, Hong, Li, Rachel W., Lu, Shen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812034/ https://www.ncbi.nlm.nih.gov/pubmed/24205245 http://dx.doi.org/10.1371/journal.pone.0078500

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