In Pulmonary Paracoccidioidomycosis IL-10 Deficiency Leads to Increased Immunity and Regressive Infection without Enhancing Tissue Pathology

BACKGROUND: Cellular immunity is the main defense mechanism in paracoccidioidomycosis (PCM), the most important systemic mycosis in Latin America. Th1 immunity and IFN-γ activated macrophages are fundamental to immunoprotection that is antagonized by IL-10, an anti-inflammatory cytokine. Both in hum...

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Detalles Bibliográficos
Autores principales: Costa, Tânia A., Bazan, Silvia B., Feriotti, Claudia, Araújo, Eliseu F., Bassi, Ênio J., Loures, Flávio V., Calich, Vera L. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812093/
https://www.ncbi.nlm.nih.gov/pubmed/24205424
http://dx.doi.org/10.1371/journal.pntd.0002512

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