The Adenylyl Cyclase Inhibitor MDL-12,330A Potentiates Insulin Secretion via Blockade of Voltage-Dependent K(+) Channels in Pancreatic Beta Cells

OBJECTIVE: Adenylyl cyclases (ACs) play important role in regulating pancreatic beta cell growth, survival and secretion through the synthesis of cyclic AMP (cAMP). MDL-12,330A and SQ 22536 are two AC inhibitors used widely to establish the role of ACs. The goal of this study was to examine the effe...

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Detalles Bibliográficos
Autores principales: Li, Xiaodong, Guo, Qing, Gao, Jingying, Yang, Jing, Zhang, Wan, Liang, Yueqin, Wu, Dongmei, Liu, Yunfeng, Weng, Jianping, Li, Qingshan, Zhang, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812155/
https://www.ncbi.nlm.nih.gov/pubmed/24205033
http://dx.doi.org/10.1371/journal.pone.0077934

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