A Comparative Analysis of the Ubiquitination Kinetics of Multiple Degrons to Identify an Ideal Targeting Sequence for a Proteasome Reporter

The ubiquitin proteasome system (UPS) is the primary pathway responsible for the recognition and degradation of misfolded, damaged, or tightly regulated proteins. The conjugation of a polyubiquitin chain, or polyubiquitination, to a target protein requires an increasingly diverse cascade of enzymes...

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Detalles Bibliográficos
Autores principales: Melvin, Adam T., Woss, Gregery S., Park, Jessica H., Dumberger, Lukas D., Waters, Marcey L., Allbritton, Nancy L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812159/
https://www.ncbi.nlm.nih.gov/pubmed/24205101
http://dx.doi.org/10.1371/journal.pone.0078082

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