Methylated DNA Binding Domain Protein 2 (MBD2) Coordinately Silences Gene Expression through Activation of the MicroRNA hsa-mir-496 Promoter in Breast Cancer Cell Line

Methylated DNA binding protein 2 (MBD2) binds methylated promoters and suppresses transcription in cis through recruitment of a chromatin modification repressor complex. We show here a new mechanism of action for MBD2: suppression of gene expression indirectly through activation of microRNA hsa-mir-...

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Detalles Bibliográficos
Autores principales: Alvarado, Sebastian, Wyglinski, Joanne, Suderman, Matthew, Andrews, Stephen A., Szyf, Moshe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812180/
https://www.ncbi.nlm.nih.gov/pubmed/24204564
http://dx.doi.org/10.1371/journal.pone.0074009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812180/
https://www.ncbi.nlm.nih.gov/pubmed/24204564
http://dx.doi.org/10.1371/journal.pone.0074009

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