Humanizing mice for the identification of novel anticancer lipids targeting iNKT cells

The CD1d-dependent presentation of lipid antigens to natural killer T (NKT) cells is an integral part of the innate immune system. However, the development of anticancer therapies based on NKT-cell agonists has had limited success so far. Humanizing mice with respect to the CD1d/NKT antigen presenta...

Descripción completa

Detalles Bibliográficos
Autores principales: Wen, Xiangshu, Xiong, Ran, Dai, Zhengxi, Kim, Seil, Lawrenczyk, Agnieszka, Yuan, Weiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812196/
https://www.ncbi.nlm.nih.gov/pubmed/24179706
http://dx.doi.org/10.4161/onci.25475
Descripción
Sumario:The CD1d-dependent presentation of lipid antigens to natural killer T (NKT) cells is an integral part of the innate immune system. However, the development of anticancer therapies based on NKT-cell agonists has had limited success so far. Humanizing mice with respect to the CD1d/NKT antigen presentation system will provide a tool to identify novel lipids that exert antineoplastic functions by targeting NKT cells before the initiation of costly and lengthy clinical trials.

Ejemplares similares