Humanizing mice for the identification of novel anticancer lipids targeting iNKT cells

The CD1d-dependent presentation of lipid antigens to natural killer T (NKT) cells is an integral part of the innate immune system. However, the development of anticancer therapies based on NKT-cell agonists has had limited success so far. Humanizing mice with respect to the CD1d/NKT antigen presenta...

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Detalles Bibliográficos
Autores principales: Wen, Xiangshu, Xiong, Ran, Dai, Zhengxi, Kim, Seil, Lawrenczyk, Agnieszka, Yuan, Weiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812196/
https://www.ncbi.nlm.nih.gov/pubmed/24179706
http://dx.doi.org/10.4161/onci.25475
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author Wen, Xiangshu
Xiong, Ran
Dai, Zhengxi
Kim, Seil
Lawrenczyk, Agnieszka
Yuan, Weiming
author_facet Wen, Xiangshu
Xiong, Ran
Dai, Zhengxi
Kim, Seil
Lawrenczyk, Agnieszka
Yuan, Weiming
author_sort Wen, Xiangshu
collection PubMed
description The CD1d-dependent presentation of lipid antigens to natural killer T (NKT) cells is an integral part of the innate immune system. However, the development of anticancer therapies based on NKT-cell agonists has had limited success so far. Humanizing mice with respect to the CD1d/NKT antigen presentation system will provide a tool to identify novel lipids that exert antineoplastic functions by targeting NKT cells before the initiation of costly and lengthy clinical trials.
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spelling pubmed-38121962013-10-31 Humanizing mice for the identification of novel anticancer lipids targeting iNKT cells Wen, Xiangshu Xiong, Ran Dai, Zhengxi Kim, Seil Lawrenczyk, Agnieszka Yuan, Weiming Oncoimmunology Author's View The CD1d-dependent presentation of lipid antigens to natural killer T (NKT) cells is an integral part of the innate immune system. However, the development of anticancer therapies based on NKT-cell agonists has had limited success so far. Humanizing mice with respect to the CD1d/NKT antigen presentation system will provide a tool to identify novel lipids that exert antineoplastic functions by targeting NKT cells before the initiation of costly and lengthy clinical trials. Landes Bioscience 2013-08-01 2013-07-01 /pmc/articles/PMC3812196/ /pubmed/24179706 http://dx.doi.org/10.4161/onci.25475 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Wen, Xiangshu
Xiong, Ran
Dai, Zhengxi
Kim, Seil
Lawrenczyk, Agnieszka
Yuan, Weiming
Humanizing mice for the identification of novel anticancer lipids targeting iNKT cells
title Humanizing mice for the identification of novel anticancer lipids targeting iNKT cells
title_full Humanizing mice for the identification of novel anticancer lipids targeting iNKT cells
title_fullStr Humanizing mice for the identification of novel anticancer lipids targeting iNKT cells
title_full_unstemmed Humanizing mice for the identification of novel anticancer lipids targeting iNKT cells
title_short Humanizing mice for the identification of novel anticancer lipids targeting iNKT cells
title_sort humanizing mice for the identification of novel anticancer lipids targeting inkt cells
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812196/
https://www.ncbi.nlm.nih.gov/pubmed/24179706
http://dx.doi.org/10.4161/onci.25475
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