Peripheral T-cell tolerance in hosts with acute myeloid leukemia

Our laboratory investigates the immune tolerance mechanisms promoted by acute myeloid leukemia (AML). In a murine AML model, we have observed that leukemia antigen-specific T cells are specifically deleted from the host, presumably following interactions with immature host antigen-presenting cells (...

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Detalles Bibliográficos
Autores principales: Chen, Xiufen, Kline, Douglas E, Kline, Justin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812197/
https://www.ncbi.nlm.nih.gov/pubmed/24179704
http://dx.doi.org/10.4161/onci.25445
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author Chen, Xiufen
Kline, Douglas E
Kline, Justin
author_facet Chen, Xiufen
Kline, Douglas E
Kline, Justin
author_sort Chen, Xiufen
collection PubMed
description Our laboratory investigates the immune tolerance mechanisms promoted by acute myeloid leukemia (AML). In a murine AML model, we have observed that leukemia antigen-specific T cells are specifically deleted from the host, presumably following interactions with immature host antigen-presenting cells (APCs). Ongoing work focuses on identifying APC subsets that induce T-cell tolerance in AML as well as the precise mechanisms that underlie this phenomenon.
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spelling pubmed-38121972013-10-31 Peripheral T-cell tolerance in hosts with acute myeloid leukemia Chen, Xiufen Kline, Douglas E Kline, Justin Oncoimmunology Author's View Our laboratory investigates the immune tolerance mechanisms promoted by acute myeloid leukemia (AML). In a murine AML model, we have observed that leukemia antigen-specific T cells are specifically deleted from the host, presumably following interactions with immature host antigen-presenting cells (APCs). Ongoing work focuses on identifying APC subsets that induce T-cell tolerance in AML as well as the precise mechanisms that underlie this phenomenon. Landes Bioscience 2013-08-01 2013-07-01 /pmc/articles/PMC3812197/ /pubmed/24179704 http://dx.doi.org/10.4161/onci.25445 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Chen, Xiufen
Kline, Douglas E
Kline, Justin
Peripheral T-cell tolerance in hosts with acute myeloid leukemia
title Peripheral T-cell tolerance in hosts with acute myeloid leukemia
title_full Peripheral T-cell tolerance in hosts with acute myeloid leukemia
title_fullStr Peripheral T-cell tolerance in hosts with acute myeloid leukemia
title_full_unstemmed Peripheral T-cell tolerance in hosts with acute myeloid leukemia
title_short Peripheral T-cell tolerance in hosts with acute myeloid leukemia
title_sort peripheral t-cell tolerance in hosts with acute myeloid leukemia
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812197/
https://www.ncbi.nlm.nih.gov/pubmed/24179704
http://dx.doi.org/10.4161/onci.25445
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