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Recruitment of γδ T lymphocytes to tumors: A new role for the pleiotropic chemokine CCL2
Despite the promise of targeting γδ T cells for cancer immunotherapy, the mechanisms underpinning the recruitment of this T-cell subsets to neoplastic lesions remain poorly understood. We have recently identified the pro-inflammatory chemokine CCL2 and its receptor CCR2 as key molecular determinants...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Landes Bioscience
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812202/ https://www.ncbi.nlm.nih.gov/pubmed/24179705 http://dx.doi.org/10.4161/onci.25461 |
| _version_ | 1782288950380986368 |
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| author | Lança, Telma Silva-Santos, Bruno |
| author_facet | Lança, Telma Silva-Santos, Bruno |
| author_sort | Lança, Telma |
| collection | PubMed |
| description | Despite the promise of targeting γδ T cells for cancer immunotherapy, the mechanisms underpinning the recruitment of this T-cell subsets to neoplastic lesions remain poorly understood. We have recently identified the pro-inflammatory chemokine CCL2 and its receptor CCR2 as key molecular determinants of γδ T-cell migration and tumor infiltration. |
| format | Online Article Text |
| id | pubmed-3812202 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2013 |
| publisher | Landes Bioscience |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-38122022013-10-31 Recruitment of γδ T lymphocytes to tumors: A new role for the pleiotropic chemokine CCL2 Lança, Telma Silva-Santos, Bruno Oncoimmunology Author's View Despite the promise of targeting γδ T cells for cancer immunotherapy, the mechanisms underpinning the recruitment of this T-cell subsets to neoplastic lesions remain poorly understood. We have recently identified the pro-inflammatory chemokine CCL2 and its receptor CCR2 as key molecular determinants of γδ T-cell migration and tumor infiltration. Landes Bioscience 2013-08-01 2013-07-01 /pmc/articles/PMC3812202/ /pubmed/24179705 http://dx.doi.org/10.4161/onci.25461 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
| spellingShingle | Author's View Lança, Telma Silva-Santos, Bruno Recruitment of γδ T lymphocytes to tumors: A new role for the pleiotropic chemokine CCL2 |
| title | Recruitment of γδ T lymphocytes to tumors: A new role for the pleiotropic chemokine CCL2 |
| title_full | Recruitment of γδ T lymphocytes to tumors: A new role for the pleiotropic chemokine CCL2 |
| title_fullStr | Recruitment of γδ T lymphocytes to tumors: A new role for the pleiotropic chemokine CCL2 |
| title_full_unstemmed | Recruitment of γδ T lymphocytes to tumors: A new role for the pleiotropic chemokine CCL2 |
| title_short | Recruitment of γδ T lymphocytes to tumors: A new role for the pleiotropic chemokine CCL2 |
| title_sort | recruitment of γδ t lymphocytes to tumors: a new role for the pleiotropic chemokine ccl2 |
| topic | Author's View |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812202/ https://www.ncbi.nlm.nih.gov/pubmed/24179705 http://dx.doi.org/10.4161/onci.25461 |
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