Synaptic Metaplasticity Underlies Tetanic Potentiation in Lymnaea: A Novel Paradigm

We present a mathematical model that explains and interprets a novel form of short-term potentiation, which was found to be use-, but not time-dependent, in experiments done on Lymnaea neurons. The high degree of potentiation is explained using a model of synaptic metaplasticity, while the use-depen...

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Detalles Bibliográficos
Autores principales: Mehta, Anita, Luck, Jean-Marc, Luk, Collin C., Syed, Naweed I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812211/
https://www.ncbi.nlm.nih.gov/pubmed/24205089
http://dx.doi.org/10.1371/journal.pone.0078056
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author Mehta, Anita
Luck, Jean-Marc
Luk, Collin C.
Syed, Naweed I.
author_facet Mehta, Anita
Luck, Jean-Marc
Luk, Collin C.
Syed, Naweed I.
author_sort Mehta, Anita
collection PubMed
description We present a mathematical model that explains and interprets a novel form of short-term potentiation, which was found to be use-, but not time-dependent, in experiments done on Lymnaea neurons. The high degree of potentiation is explained using a model of synaptic metaplasticity, while the use-dependence (which is critically reliant on the presence of kinase in the experiment) is explained using a model of a stochastic and bistable biological switch.
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spelling pubmed-38122112013-11-07 Synaptic Metaplasticity Underlies Tetanic Potentiation in Lymnaea: A Novel Paradigm Mehta, Anita Luck, Jean-Marc Luk, Collin C. Syed, Naweed I. PLoS One Research Article We present a mathematical model that explains and interprets a novel form of short-term potentiation, which was found to be use-, but not time-dependent, in experiments done on Lymnaea neurons. The high degree of potentiation is explained using a model of synaptic metaplasticity, while the use-dependence (which is critically reliant on the presence of kinase in the experiment) is explained using a model of a stochastic and bistable biological switch. Public Library of Science 2013-10-29 /pmc/articles/PMC3812211/ /pubmed/24205089 http://dx.doi.org/10.1371/journal.pone.0078056 Text en © 2013 Mehta et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Mehta, Anita
Luck, Jean-Marc
Luk, Collin C.
Syed, Naweed I.
Synaptic Metaplasticity Underlies Tetanic Potentiation in Lymnaea: A Novel Paradigm
title Synaptic Metaplasticity Underlies Tetanic Potentiation in Lymnaea: A Novel Paradigm
title_full Synaptic Metaplasticity Underlies Tetanic Potentiation in Lymnaea: A Novel Paradigm
title_fullStr Synaptic Metaplasticity Underlies Tetanic Potentiation in Lymnaea: A Novel Paradigm
title_full_unstemmed Synaptic Metaplasticity Underlies Tetanic Potentiation in Lymnaea: A Novel Paradigm
title_short Synaptic Metaplasticity Underlies Tetanic Potentiation in Lymnaea: A Novel Paradigm
title_sort synaptic metaplasticity underlies tetanic potentiation in lymnaea: a novel paradigm
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812211/
https://www.ncbi.nlm.nih.gov/pubmed/24205089
http://dx.doi.org/10.1371/journal.pone.0078056
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