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Sensitivity Analysis of Weight Reduction Results of an Observational Cohort Study in Overweight and Obese Children and Adolescents in Germany: The Evakuj Study
In the German EvAKuJ observational cohort study, changes in the body mass index standard deviation score (BMI–SDS) of overweight and obese children and adolescents as primary outcome of multimodal (short, inpatient or long, outpatient) weight-loss interventions are difficult to interpret. Published...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PAGEPress Publications, Pavia, Italy
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812533/ https://www.ncbi.nlm.nih.gov/pubmed/24198928 http://dx.doi.org/10.4081/pr.2013.e16 |
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author | Böhler, Thomas Goldapp, Cornelia Mann, Reinhard Reinehr, Thomas Bullinger, Monika Holl, Reinhard Hoffmeister, Ulrike van Egmond-Fröhlich, Andreas Ravens-Sieberer, Ulrike Wille, Nora Westenhöfer, Joachim Bengel, Jürgen |
author_facet | Böhler, Thomas Goldapp, Cornelia Mann, Reinhard Reinehr, Thomas Bullinger, Monika Holl, Reinhard Hoffmeister, Ulrike van Egmond-Fröhlich, Andreas Ravens-Sieberer, Ulrike Wille, Nora Westenhöfer, Joachim Bengel, Jürgen |
author_sort | Böhler, Thomas |
collection | PubMed |
description | In the German EvAKuJ observational cohort study, changes in the body mass index standard deviation score (BMI–SDS) of overweight and obese children and adolescents as primary outcome of multimodal (short, inpatient or long, outpatient) weight-loss interventions are difficult to interpret. Published intention-to-treat (ITT) and per protocol data obtained at the end of the intervention (T(1)), one year (T(2)), and two years (T(3)) after its end were used for sensitivity analysis of treatment success rates. The odds ratio and the number needed to treat (NNT) for BMI–SDS reduction of at least −0.2 (successful treatment) and at least −0.5 (good treatment success) were related to spontaneous BMI-SDS reduction rates in a hypothetical control group (control event rate, CER). At T(1), treatment seems to be effective up to a CER of 10% in inpatients and of 5% in outpatients. ITT analysis, compromised by a loss to follow-up of 81 to 90% (inpatients) and 57 to 66% (outpatients), indicated that treatment may become less effective at a CER above 1% in inpatients (e.g., successful treatment at T(2): NNT=106, at T(3): NNT=51), and above 5% in outpatients (successful treatment at T(2): NNT=7, at T(3): NNT=8; good treatment success at T(2) and T(3): NNT=25). Positive short-term effects of inpatient treatment of overweight and obese children and adolescents may not be maintained in the long term. Long-term effectiveness of outpatient treatment may depend on age and the degree of overweight. |
format | Online Article Text |
id | pubmed-3812533 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | PAGEPress Publications, Pavia, Italy |
record_format | MEDLINE/PubMed |
spelling | pubmed-38125332013-11-06 Sensitivity Analysis of Weight Reduction Results of an Observational Cohort Study in Overweight and Obese Children and Adolescents in Germany: The Evakuj Study Böhler, Thomas Goldapp, Cornelia Mann, Reinhard Reinehr, Thomas Bullinger, Monika Holl, Reinhard Hoffmeister, Ulrike van Egmond-Fröhlich, Andreas Ravens-Sieberer, Ulrike Wille, Nora Westenhöfer, Joachim Bengel, Jürgen Pediatr Rep Article In the German EvAKuJ observational cohort study, changes in the body mass index standard deviation score (BMI–SDS) of overweight and obese children and adolescents as primary outcome of multimodal (short, inpatient or long, outpatient) weight-loss interventions are difficult to interpret. Published intention-to-treat (ITT) and per protocol data obtained at the end of the intervention (T(1)), one year (T(2)), and two years (T(3)) after its end were used for sensitivity analysis of treatment success rates. The odds ratio and the number needed to treat (NNT) for BMI–SDS reduction of at least −0.2 (successful treatment) and at least −0.5 (good treatment success) were related to spontaneous BMI-SDS reduction rates in a hypothetical control group (control event rate, CER). At T(1), treatment seems to be effective up to a CER of 10% in inpatients and of 5% in outpatients. ITT analysis, compromised by a loss to follow-up of 81 to 90% (inpatients) and 57 to 66% (outpatients), indicated that treatment may become less effective at a CER above 1% in inpatients (e.g., successful treatment at T(2): NNT=106, at T(3): NNT=51), and above 5% in outpatients (successful treatment at T(2): NNT=7, at T(3): NNT=8; good treatment success at T(2) and T(3): NNT=25). Positive short-term effects of inpatient treatment of overweight and obese children and adolescents may not be maintained in the long term. Long-term effectiveness of outpatient treatment may depend on age and the degree of overweight. PAGEPress Publications, Pavia, Italy 2013-10-07 /pmc/articles/PMC3812533/ /pubmed/24198928 http://dx.doi.org/10.4081/pr.2013.e16 Text en ©Copyright T. Böhler et al. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Article Böhler, Thomas Goldapp, Cornelia Mann, Reinhard Reinehr, Thomas Bullinger, Monika Holl, Reinhard Hoffmeister, Ulrike van Egmond-Fröhlich, Andreas Ravens-Sieberer, Ulrike Wille, Nora Westenhöfer, Joachim Bengel, Jürgen Sensitivity Analysis of Weight Reduction Results of an Observational Cohort Study in Overweight and Obese Children and Adolescents in Germany: The Evakuj Study |
title | Sensitivity Analysis of Weight Reduction Results of an Observational Cohort Study in Overweight and Obese Children and Adolescents in Germany: The Evakuj Study |
title_full | Sensitivity Analysis of Weight Reduction Results of an Observational Cohort Study in Overweight and Obese Children and Adolescents in Germany: The Evakuj Study |
title_fullStr | Sensitivity Analysis of Weight Reduction Results of an Observational Cohort Study in Overweight and Obese Children and Adolescents in Germany: The Evakuj Study |
title_full_unstemmed | Sensitivity Analysis of Weight Reduction Results of an Observational Cohort Study in Overweight and Obese Children and Adolescents in Germany: The Evakuj Study |
title_short | Sensitivity Analysis of Weight Reduction Results of an Observational Cohort Study in Overweight and Obese Children and Adolescents in Germany: The Evakuj Study |
title_sort | sensitivity analysis of weight reduction results of an observational cohort study in overweight and obese children and adolescents in germany: the evakuj study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812533/ https://www.ncbi.nlm.nih.gov/pubmed/24198928 http://dx.doi.org/10.4081/pr.2013.e16 |
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