Indolo[3,2-a]carbazoles from a Deep-Water Sponge of the Genus Asteropus

[Image: see text] Two new indolo[3,2-a]carbazoles (1, 2) were isolated from a deep-water collection of a sponge of the genus Asteropus. The structures of 1 and 2 were determined through the analysis of spectroscopic data including mass spectrometry and 2D-NMR. Compound 1 showed minimum inhibitory co...

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Autores principales: Russell, Floyd, Harmody, Dedra, McCarthy, Peter J., Pomponi, Shirley A., Wright, Amy E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society and American Society of Pharmacognosy 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812703/
https://www.ncbi.nlm.nih.gov/pubmed/24063539
http://dx.doi.org/10.1021/np400501u
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author Russell, Floyd
Harmody, Dedra
McCarthy, Peter J.
Pomponi, Shirley A.
Wright, Amy E.
author_facet Russell, Floyd
Harmody, Dedra
McCarthy, Peter J.
Pomponi, Shirley A.
Wright, Amy E.
author_sort Russell, Floyd
collection PubMed
description [Image: see text] Two new indolo[3,2-a]carbazoles (1, 2) were isolated from a deep-water collection of a sponge of the genus Asteropus. The structures of 1 and 2 were determined through the analysis of spectroscopic data including mass spectrometry and 2D-NMR. Compound 1 showed minimum inhibitory concentrations of 25 μg/mL against the fungal pathogen Candida albicans and 50 μg/mL against methicillin-resistant Staphylococcus aureus (MRSA). Compounds 1 and 2 showed no cytotoxicity against the PANC1 human pancreatic carcinoma and NCI/ADR-RES ovarian adenocarcinoma cell lines at our standard test concentration of 5 μg/mL.
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spelling pubmed-38127032013-10-30 Indolo[3,2-a]carbazoles from a Deep-Water Sponge of the Genus Asteropus Russell, Floyd Harmody, Dedra McCarthy, Peter J. Pomponi, Shirley A. Wright, Amy E. J Nat Prod [Image: see text] Two new indolo[3,2-a]carbazoles (1, 2) were isolated from a deep-water collection of a sponge of the genus Asteropus. The structures of 1 and 2 were determined through the analysis of spectroscopic data including mass spectrometry and 2D-NMR. Compound 1 showed minimum inhibitory concentrations of 25 μg/mL against the fungal pathogen Candida albicans and 50 μg/mL against methicillin-resistant Staphylococcus aureus (MRSA). Compounds 1 and 2 showed no cytotoxicity against the PANC1 human pancreatic carcinoma and NCI/ADR-RES ovarian adenocarcinoma cell lines at our standard test concentration of 5 μg/mL. American Chemical Society and American Society of Pharmacognosy 2013-09-24 2013-10-25 /pmc/articles/PMC3812703/ /pubmed/24063539 http://dx.doi.org/10.1021/np400501u Text en Copyright © 2013 American Chemical Society and American Society of Pharmacognosy Terms of Use (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html)
spellingShingle Russell, Floyd
Harmody, Dedra
McCarthy, Peter J.
Pomponi, Shirley A.
Wright, Amy E.
Indolo[3,2-a]carbazoles from a Deep-Water Sponge of the Genus Asteropus
title Indolo[3,2-a]carbazoles from a Deep-Water Sponge of the Genus Asteropus
title_full Indolo[3,2-a]carbazoles from a Deep-Water Sponge of the Genus Asteropus
title_fullStr Indolo[3,2-a]carbazoles from a Deep-Water Sponge of the Genus Asteropus
title_full_unstemmed Indolo[3,2-a]carbazoles from a Deep-Water Sponge of the Genus Asteropus
title_short Indolo[3,2-a]carbazoles from a Deep-Water Sponge of the Genus Asteropus
title_sort indolo[3,2-a]carbazoles from a deep-water sponge of the genus asteropus
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812703/
https://www.ncbi.nlm.nih.gov/pubmed/24063539
http://dx.doi.org/10.1021/np400501u
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AT pomponishirleya indolo32acarbazolesfromadeepwaterspongeofthegenusasteropus
AT wrightamye indolo32acarbazolesfromadeepwaterspongeofthegenusasteropus

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