Cargando…
Osteoclasts Lose Innate Inflammatory Reactivity to Metal and Polymer Implant Debris Compared to Monocytes/Macrophages
Long-term aseptic failures of joint replacements are generally attributed to implant debris-induced inflammation and osteolysis. This response is largely mediated by immune and bone cells (monocytes/macrophages and osteoclasts, respectively), that in the presence of implant debris (e.g. metal partic...
Autores principales: | Yadav, Jessica, Samelko, Lauryn, Gilvar, Phil, McAllister, Kyron, Hallab, Nadim James |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bentham Open
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812786/ https://www.ncbi.nlm.nih.gov/pubmed/24198853 http://dx.doi.org/10.2174/1874325001307010605 |
Ejemplares similares
-
Cobalt Alloy Implant Debris Induces Inflammation and Bone Loss Primarily through Danger Signaling, Not TLR4 Activation: Implications for DAMP-ening Implant Related Inflammation
por: Samelko, Lauryn, et al.
Publicado: (2016) -
CoCrMo alloy vs. UHMWPE Particulate Implant Debris Induces Sex Dependent Aseptic Osteolysis Responses In Vivo using a Murine Model
por: Landgraeber, Stefan, et al.
Publicado: (2018) -
Metal-induced delayed type hypersensitivity responses potentiate particle induced osteolysis in a sex and age dependent manner
por: Samelko, Lauryn, et al.
Publicado: (2021) -
Cobalt-Alloy Implant Debris Induce HIF-1α Hypoxia Associated Responses: A Mechanism for Metal-Specific Orthopedic Implant Failure
por: Samelko, Lauryn, et al.
Publicado: (2013) -
Transition from metal-DTH resistance to susceptibility is facilitated by NLRP3 inflammasome signaling induced Th17 reactivity: Implications for orthopedic implants
por: Samelko, Lauryn, et al.
Publicado: (2019)