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Video-EEG recordings in full-term neonates of diabetic mothers: observational study
OBJETIVE: To determine whether full-term newborn infants of diabetic mothers (IDM) present immature/disorganised EEG patterns in the immediate neonatal period, and whether there was any relationship with maternal glycaemic control. DESIGN AND SETTING: Cohort study with an incidental sample performed...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812861/ https://www.ncbi.nlm.nih.gov/pubmed/23873907 http://dx.doi.org/10.1136/archdischild-2013-304283 |
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author | Castro Conde, José Ramón González González, Nieves Luisa González Barrios, Desiré González Campo, Candelaria Suárez Hernández, Yaiza Sosa Comino, Elena |
author_facet | Castro Conde, José Ramón González González, Nieves Luisa González Barrios, Desiré González Campo, Candelaria Suárez Hernández, Yaiza Sosa Comino, Elena |
author_sort | Castro Conde, José Ramón |
collection | PubMed |
description | OBJETIVE: To determine whether full-term newborn infants of diabetic mothers (IDM) present immature/disorganised EEG patterns in the immediate neonatal period, and whether there was any relationship with maternal glycaemic control. DESIGN AND SETTING: Cohort study with an incidental sample performed in a tertiary hospital neonatal unit. PATIENTS: 23 IDM and 22 healthy newborns born between 2010 and 2013. INTERVENTIONS: All underwent video-EEG recording lasting >90 min at 48–72 h of life. MAIN OUTCOME MEASURES: We analysed the percentage of indeterminate sleep, transient sharp waves per hour and mature-for-gestational age EEG patterns (discontinuity, maximum duration of interburst interval (IBI), asynchrony, asymmetry, δ brushes, encoches frontales and α/θ rolandic activity). The group of IDM was divided into two subgroups according to maternal HbA1c: (1) HbA1c≥6% and (2) HbA1c<6%. RESULTS: Compared with healthy newborns, IDM presented significantly higher percentage of indeterminate sleep (57% vs 25%; p<0.001), discontinuity (2.5% vs 0%; p=0.044) and δ brushes in the bursts (6% vs 3%; p=0.024); higher duration of IBI (0.3 s vs 0 s; p=0.017); fewer encoches frontales (7/h vs 35/h; p<0.001), reduced θ/α rolandic activity (3/h vs 9/h; p<0.001); and more transient sharp waves (25/h vs 5/h; p<0.001). IDM with maternal HbA1c≥6% showed greater percentage of δ brushes in the burst (14% vs 4%; p=0.007). CONCLUSIONS: Full-term IDM newborns showed video-EEG features of abnormal development of brain function. Maternal HbA1c levels<6% during pregnancy could minimise the risk of cerebral dysmaturity. |
format | Online Article Text |
id | pubmed-3812861 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-38128612013-10-31 Video-EEG recordings in full-term neonates of diabetic mothers: observational study Castro Conde, José Ramón González González, Nieves Luisa González Barrios, Desiré González Campo, Candelaria Suárez Hernández, Yaiza Sosa Comino, Elena Arch Dis Child Fetal Neonatal Ed Original Article OBJETIVE: To determine whether full-term newborn infants of diabetic mothers (IDM) present immature/disorganised EEG patterns in the immediate neonatal period, and whether there was any relationship with maternal glycaemic control. DESIGN AND SETTING: Cohort study with an incidental sample performed in a tertiary hospital neonatal unit. PATIENTS: 23 IDM and 22 healthy newborns born between 2010 and 2013. INTERVENTIONS: All underwent video-EEG recording lasting >90 min at 48–72 h of life. MAIN OUTCOME MEASURES: We analysed the percentage of indeterminate sleep, transient sharp waves per hour and mature-for-gestational age EEG patterns (discontinuity, maximum duration of interburst interval (IBI), asynchrony, asymmetry, δ brushes, encoches frontales and α/θ rolandic activity). The group of IDM was divided into two subgroups according to maternal HbA1c: (1) HbA1c≥6% and (2) HbA1c<6%. RESULTS: Compared with healthy newborns, IDM presented significantly higher percentage of indeterminate sleep (57% vs 25%; p<0.001), discontinuity (2.5% vs 0%; p=0.044) and δ brushes in the bursts (6% vs 3%; p=0.024); higher duration of IBI (0.3 s vs 0 s; p=0.017); fewer encoches frontales (7/h vs 35/h; p<0.001), reduced θ/α rolandic activity (3/h vs 9/h; p<0.001); and more transient sharp waves (25/h vs 5/h; p<0.001). IDM with maternal HbA1c≥6% showed greater percentage of δ brushes in the burst (14% vs 4%; p=0.007). CONCLUSIONS: Full-term IDM newborns showed video-EEG features of abnormal development of brain function. Maternal HbA1c levels<6% during pregnancy could minimise the risk of cerebral dysmaturity. BMJ Publishing Group 2013-11 2013-07-19 /pmc/articles/PMC3812861/ /pubmed/23873907 http://dx.doi.org/10.1136/archdischild-2013-304283 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Original Article Castro Conde, José Ramón González González, Nieves Luisa González Barrios, Desiré González Campo, Candelaria Suárez Hernández, Yaiza Sosa Comino, Elena Video-EEG recordings in full-term neonates of diabetic mothers: observational study |
title | Video-EEG recordings in full-term neonates of diabetic mothers: observational study |
title_full | Video-EEG recordings in full-term neonates of diabetic mothers: observational study |
title_fullStr | Video-EEG recordings in full-term neonates of diabetic mothers: observational study |
title_full_unstemmed | Video-EEG recordings in full-term neonates of diabetic mothers: observational study |
title_short | Video-EEG recordings in full-term neonates of diabetic mothers: observational study |
title_sort | video-eeg recordings in full-term neonates of diabetic mothers: observational study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812861/ https://www.ncbi.nlm.nih.gov/pubmed/23873907 http://dx.doi.org/10.1136/archdischild-2013-304283 |
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