The vesicular ATPase: A missing link between acidification and exocytosis

The vesicular adenosine triphosphatase (ATPase) acidifies intracellular compartments, including synaptic vesicles and secretory granules. A controversy about a second function of this ATPase in exocytosis has been fuelled by questions about multiple putative roles of acidification in the exocytic pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Dong, Hiesinger, P. Robin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812979/
https://www.ncbi.nlm.nih.gov/pubmed/24165933
http://dx.doi.org/10.1083/jcb.201309130
_version_ 1782289025647771648
author Wang, Dong
Hiesinger, P. Robin
author_facet Wang, Dong
Hiesinger, P. Robin
author_sort Wang, Dong
collection PubMed
description The vesicular adenosine triphosphatase (ATPase) acidifies intracellular compartments, including synaptic vesicles and secretory granules. A controversy about a second function of this ATPase in exocytosis has been fuelled by questions about multiple putative roles of acidification in the exocytic process. Now, Poëa-Guyon et al. (2013. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201303104) present new evidence that the vesicular ATPase performs separate acidification and exocytosis roles and propose a mechanism for how these two functions are causally linked.
format Online
Article
Text
id pubmed-3812979
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-38129792014-04-28 The vesicular ATPase: A missing link between acidification and exocytosis Wang, Dong Hiesinger, P. Robin J Cell Biol Reviews The vesicular adenosine triphosphatase (ATPase) acidifies intracellular compartments, including synaptic vesicles and secretory granules. A controversy about a second function of this ATPase in exocytosis has been fuelled by questions about multiple putative roles of acidification in the exocytic process. Now, Poëa-Guyon et al. (2013. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201303104) present new evidence that the vesicular ATPase performs separate acidification and exocytosis roles and propose a mechanism for how these two functions are causally linked. The Rockefeller University Press 2013-10-28 /pmc/articles/PMC3812979/ /pubmed/24165933 http://dx.doi.org/10.1083/jcb.201309130 Text en © 2013 Wang and Hiesinger This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Wang, Dong
Hiesinger, P. Robin
The vesicular ATPase: A missing link between acidification and exocytosis
title The vesicular ATPase: A missing link between acidification and exocytosis
title_full The vesicular ATPase: A missing link between acidification and exocytosis
title_fullStr The vesicular ATPase: A missing link between acidification and exocytosis
title_full_unstemmed The vesicular ATPase: A missing link between acidification and exocytosis
title_short The vesicular ATPase: A missing link between acidification and exocytosis
title_sort vesicular atpase: a missing link between acidification and exocytosis
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812979/
https://www.ncbi.nlm.nih.gov/pubmed/24165933
http://dx.doi.org/10.1083/jcb.201309130
work_keys_str_mv AT wangdong thevesicularatpaseamissinglinkbetweenacidificationandexocytosis
AT hiesingerprobin thevesicularatpaseamissinglinkbetweenacidificationandexocytosis
AT wangdong vesicularatpaseamissinglinkbetweenacidificationandexocytosis
AT hiesingerprobin vesicularatpaseamissinglinkbetweenacidificationandexocytosis

Ejemplares similares