Cytotoxic Effect of Some 1, 4-Dihydropyridine Derivatives Containing Nitroimidazole Moiety

The 1,4-dihydropyridine (DHP) derivatives are a known class of calcium channel blockers. Some derivatives of DHP showed significant cytotoxicity. It was shown that this effect may not be the result of interaction with Ca(2+) channels. In this study, we performed an investigation about the intrinsic...

Descripción completa

Detalles Bibliográficos
Autores principales: Miri, Ramin, Javidnia, Katayoun, Amirghofran, Zahra, Salimi, Seyyed Hossein, Sabetghadam, Zahra, Meili, Savis, Mehdipour, Ahmad Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813032/
https://www.ncbi.nlm.nih.gov/pubmed/24250381
_version_ 1782289033382068224
author Miri, Ramin
Javidnia, Katayoun
Amirghofran, Zahra
Salimi, Seyyed Hossein
Sabetghadam, Zahra
Meili, Savis
Mehdipour, Ahmad Reza
author_facet Miri, Ramin
Javidnia, Katayoun
Amirghofran, Zahra
Salimi, Seyyed Hossein
Sabetghadam, Zahra
Meili, Savis
Mehdipour, Ahmad Reza
author_sort Miri, Ramin
collection PubMed
description The 1,4-dihydropyridine (DHP) derivatives are a known class of calcium channel blockers. Some derivatives of DHP showed significant cytotoxicity. It was shown that this effect may not be the result of interaction with Ca(2+) channels. In this study, we performed an investigation about the intrinsic cytotoxicity of some derivatives of DHP containing nitroimidazole moiety on their C4 position on four different cancer cell lines (Raji, K562, Fen and HeLa). The result showed that these compounds had moderate-good cytotoxic activity. In addition, QSAR model shows the importance of N atom in cytotoxicity; Ca(2+) channels.
format Online
Article
Text
id pubmed-3813032
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Shaheed Beheshti University of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-38130322013-11-18 Cytotoxic Effect of Some 1, 4-Dihydropyridine Derivatives Containing Nitroimidazole Moiety Miri, Ramin Javidnia, Katayoun Amirghofran, Zahra Salimi, Seyyed Hossein Sabetghadam, Zahra Meili, Savis Mehdipour, Ahmad Reza Iran J Pharm Res Original Article The 1,4-dihydropyridine (DHP) derivatives are a known class of calcium channel blockers. Some derivatives of DHP showed significant cytotoxicity. It was shown that this effect may not be the result of interaction with Ca(2+) channels. In this study, we performed an investigation about the intrinsic cytotoxicity of some derivatives of DHP containing nitroimidazole moiety on their C4 position on four different cancer cell lines (Raji, K562, Fen and HeLa). The result showed that these compounds had moderate-good cytotoxic activity. In addition, QSAR model shows the importance of N atom in cytotoxicity; Ca(2+) channels. Shaheed Beheshti University of Medical Sciences 2011 /pmc/articles/PMC3813032/ /pubmed/24250381 Text en © 2011 by School of Pharmacy, Shaheed Beheshti University of Medical Sciences and Health Services This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Miri, Ramin
Javidnia, Katayoun
Amirghofran, Zahra
Salimi, Seyyed Hossein
Sabetghadam, Zahra
Meili, Savis
Mehdipour, Ahmad Reza
Cytotoxic Effect of Some 1, 4-Dihydropyridine Derivatives Containing Nitroimidazole Moiety
title Cytotoxic Effect of Some 1, 4-Dihydropyridine Derivatives Containing Nitroimidazole Moiety
title_full Cytotoxic Effect of Some 1, 4-Dihydropyridine Derivatives Containing Nitroimidazole Moiety
title_fullStr Cytotoxic Effect of Some 1, 4-Dihydropyridine Derivatives Containing Nitroimidazole Moiety
title_full_unstemmed Cytotoxic Effect of Some 1, 4-Dihydropyridine Derivatives Containing Nitroimidazole Moiety
title_short Cytotoxic Effect of Some 1, 4-Dihydropyridine Derivatives Containing Nitroimidazole Moiety
title_sort cytotoxic effect of some 1, 4-dihydropyridine derivatives containing nitroimidazole moiety
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813032/
https://www.ncbi.nlm.nih.gov/pubmed/24250381
work_keys_str_mv AT miriramin cytotoxiceffectofsome14dihydropyridinederivativescontainingnitroimidazolemoiety
AT javidniakatayoun cytotoxiceffectofsome14dihydropyridinederivativescontainingnitroimidazolemoiety
AT amirghofranzahra cytotoxiceffectofsome14dihydropyridinederivativescontainingnitroimidazolemoiety
AT salimiseyyedhossein cytotoxiceffectofsome14dihydropyridinederivativescontainingnitroimidazolemoiety
AT sabetghadamzahra cytotoxiceffectofsome14dihydropyridinederivativescontainingnitroimidazolemoiety
AT meilisavis cytotoxiceffectofsome14dihydropyridinederivativescontainingnitroimidazolemoiety
AT mehdipourahmadreza cytotoxiceffectofsome14dihydropyridinederivativescontainingnitroimidazolemoiety

Ejemplares similares