Synthesis and Antimycobacterial Activity of 2-(Phenylthio) benzoylarylhydrazone Derivatives

A series of new 2-(phenylthio) benzoylarylhydrazones were synthesized by acid-catalyzed condensation of hydrazide 3 with corresponding aldehydes. The chemical structures of the compounds were elucidated by FT-IR, (1)H-NMR and Mass spectra. All newly synthesized compounds were evaluated for their ant...

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Autores principales: Almasirad, Ali, Samiee-Sadr, Somayeh, Shafiee, Abbas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813053/
https://www.ncbi.nlm.nih.gov/pubmed/24250407
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author Almasirad, Ali
Samiee-Sadr, Somayeh
Shafiee, Abbas
author_facet Almasirad, Ali
Samiee-Sadr, Somayeh
Shafiee, Abbas
author_sort Almasirad, Ali
collection PubMed
description A series of new 2-(phenylthio) benzoylarylhydrazones were synthesized by acid-catalyzed condensation of hydrazide 3 with corresponding aldehydes. The chemical structures of the compounds were elucidated by FT-IR, (1)H-NMR and Mass spectra. All newly synthesized compounds were evaluated for their antimycobacterial activities against Mycobacterium tuberculosis H(37)Rv using the microplatealamar blue assay (MABA). Compounds 4f (5-Nitro-2-furyl analogue) and 4g (5-Nitro-2-thienyl analogue) showed antimycobacterial activity with IC(90), 7.57 and 2.96 μg/mL, respectively.
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spelling pubmed-38130532013-11-18 Synthesis and Antimycobacterial Activity of 2-(Phenylthio) benzoylarylhydrazone Derivatives Almasirad, Ali Samiee-Sadr, Somayeh Shafiee, Abbas Iran J Pharm Res Original Article A series of new 2-(phenylthio) benzoylarylhydrazones were synthesized by acid-catalyzed condensation of hydrazide 3 with corresponding aldehydes. The chemical structures of the compounds were elucidated by FT-IR, (1)H-NMR and Mass spectra. All newly synthesized compounds were evaluated for their antimycobacterial activities against Mycobacterium tuberculosis H(37)Rv using the microplatealamar blue assay (MABA). Compounds 4f (5-Nitro-2-furyl analogue) and 4g (5-Nitro-2-thienyl analogue) showed antimycobacterial activity with IC(90), 7.57 and 2.96 μg/mL, respectively. Shaheed Beheshti University of Medical Sciences 2011 /pmc/articles/PMC3813053/ /pubmed/24250407 Text en © 2011 by School of Pharmacy, Shaheed Beheshti University of Medical Sciences and Health Services This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Almasirad, Ali
Samiee-Sadr, Somayeh
Shafiee, Abbas
Synthesis and Antimycobacterial Activity of 2-(Phenylthio) benzoylarylhydrazone Derivatives
title Synthesis and Antimycobacterial Activity of 2-(Phenylthio) benzoylarylhydrazone Derivatives
title_full Synthesis and Antimycobacterial Activity of 2-(Phenylthio) benzoylarylhydrazone Derivatives
title_fullStr Synthesis and Antimycobacterial Activity of 2-(Phenylthio) benzoylarylhydrazone Derivatives
title_full_unstemmed Synthesis and Antimycobacterial Activity of 2-(Phenylthio) benzoylarylhydrazone Derivatives
title_short Synthesis and Antimycobacterial Activity of 2-(Phenylthio) benzoylarylhydrazone Derivatives
title_sort synthesis and antimycobacterial activity of 2-(phenylthio) benzoylarylhydrazone derivatives
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813053/
https://www.ncbi.nlm.nih.gov/pubmed/24250407
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