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Physical and Chemical Stability of Mycophenolate Mofetil (MMF) Suspension Prepared at the Hospital
To evaluate the physical and chemical stability of a suspension of mycophenolate mofetil (MMF) prepared in the hospital from commercially available MMF capsules and tablets. Extemporaneous pharmacy was used as a feasible method in this experimental study to prepare suspension form of MMF. Suspension...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shaheed Beheshti University of Medical Sciences
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813101/ https://www.ncbi.nlm.nih.gov/pubmed/24250439 |
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author | Fahimi, Fanak Baniasadi, Shadi Mortazavi, Seyed Alireza Dehghan, Hanie Zarghi, Afshin |
author_facet | Fahimi, Fanak Baniasadi, Shadi Mortazavi, Seyed Alireza Dehghan, Hanie Zarghi, Afshin |
author_sort | Fahimi, Fanak |
collection | PubMed |
description | To evaluate the physical and chemical stability of a suspension of mycophenolate mofetil (MMF) prepared in the hospital from commercially available MMF capsules and tablets. Extemporaneous pharmacy was used as a feasible method in this experimental study to prepare suspension form of MMF. Suspension formulations were prepared from both tablets and capsules forms of MMF. Thereafter the stability parameters such as pH, microbial control, thermal and physical stability and particle sizes were evaluated. The amount of MMF, in the suspension was measured at various time points by HPLC. The HPLC method showed that concentration of suspensions prepared from tablets and capsules were 49 mg/mL and 50 mg/mL at time 0, respectively. The effective amount of suspensions prepared from capsules was 101% at time 0, 100% after 7 days, 98% after 14 days, and less than 70% after 28 days. According to the obtained results in this study, capsule-based suspension was stable for as long as 14 days at 5°C. This formulation appears to be clinically acceptable and provides a convenient dosage form for pediatric patients and for adults during the early postoperative period. |
format | Online Article Text |
id | pubmed-3813101 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Shaheed Beheshti University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-38131012013-11-18 Physical and Chemical Stability of Mycophenolate Mofetil (MMF) Suspension Prepared at the Hospital Fahimi, Fanak Baniasadi, Shadi Mortazavi, Seyed Alireza Dehghan, Hanie Zarghi, Afshin Iran J Pharm Res Original Article To evaluate the physical and chemical stability of a suspension of mycophenolate mofetil (MMF) prepared in the hospital from commercially available MMF capsules and tablets. Extemporaneous pharmacy was used as a feasible method in this experimental study to prepare suspension form of MMF. Suspension formulations were prepared from both tablets and capsules forms of MMF. Thereafter the stability parameters such as pH, microbial control, thermal and physical stability and particle sizes were evaluated. The amount of MMF, in the suspension was measured at various time points by HPLC. The HPLC method showed that concentration of suspensions prepared from tablets and capsules were 49 mg/mL and 50 mg/mL at time 0, respectively. The effective amount of suspensions prepared from capsules was 101% at time 0, 100% after 7 days, 98% after 14 days, and less than 70% after 28 days. According to the obtained results in this study, capsule-based suspension was stable for as long as 14 days at 5°C. This formulation appears to be clinically acceptable and provides a convenient dosage form for pediatric patients and for adults during the early postoperative period. Shaheed Beheshti University of Medical Sciences 2012 /pmc/articles/PMC3813101/ /pubmed/24250439 Text en © 2012 by School of Pharmacy, Shaheed Beheshti University of Medical Sciences and Health Services This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Fahimi, Fanak Baniasadi, Shadi Mortazavi, Seyed Alireza Dehghan, Hanie Zarghi, Afshin Physical and Chemical Stability of Mycophenolate Mofetil (MMF) Suspension Prepared at the Hospital |
title | Physical and Chemical Stability of Mycophenolate Mofetil (MMF) Suspension Prepared at the Hospital |
title_full | Physical and Chemical Stability of Mycophenolate Mofetil (MMF) Suspension Prepared at the Hospital |
title_fullStr | Physical and Chemical Stability of Mycophenolate Mofetil (MMF) Suspension Prepared at the Hospital |
title_full_unstemmed | Physical and Chemical Stability of Mycophenolate Mofetil (MMF) Suspension Prepared at the Hospital |
title_short | Physical and Chemical Stability of Mycophenolate Mofetil (MMF) Suspension Prepared at the Hospital |
title_sort | physical and chemical stability of mycophenolate mofetil (mmf) suspension prepared at the hospital |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813101/ https://www.ncbi.nlm.nih.gov/pubmed/24250439 |
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