Effect of Formulation Variables on Rifampicin Loaded Alginate Beads

The present work investigated the preparation of biodegradable beads with alginate polymer by ionotropic gelation method to improve the control release properties of the antibiotic rifampicin. Ionotropic gelation method was applied to prepare beads using calcium chloride (CaCl(2)) as cationic compon...

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Detalles Bibliográficos
Autores principales: Narra, Kishore, Dhanalekshmi, Unnikrishnan, Rangaraj, Govindaraj, Raja, Devendiran, Senthil Kumar, Celladurai, Neelakanta Reddy, Pully, Baran Mandal, Asit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813113/
https://www.ncbi.nlm.nih.gov/pubmed/24250498
Descripción
Sumario:The present work investigated the preparation of biodegradable beads with alginate polymer by ionotropic gelation method to improve the control release properties of the antibiotic rifampicin. Ionotropic gelation method was applied to prepare beads using calcium chloride (CaCl(2)) as cationic component and alginate as an anionic component. In this method, adding 0.5% w/v polyvinyl alcohol (PVA) to sodium alginate (3.0% w/v) and 2% w/v of polyvinyl pyrrolidone (PVP) to the CaCl(2) solution were maintained to study the drug-loading and its released characteristics. The results showed that the addition of PVA and PVP significantly improved drug-loading, encapsulation efficiency and release characteristics. This demonstrates that the ionic gelation of alginate molecules offers a flexible and easily controllable process.

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