Cargando…

A Comparative Study of Intravenous Paracetamol and Fentanyl for Pain Management in ICU

Pain in ICU patients should be managed effectively and safely. Fentanyl and Paracetamol are used frequently in ICU. However experience using IV Paracetamol in the setting of critically ill patients is limited. We evaluated the analgesic effect and adverse reactions of intravenous Paracetamol compare...

Descripción completa

Detalles Bibliográficos
Autores principales: Kouchek, Mehran, Mansouri, Behnam, Mokhtari, Majid, Goharani, Reza, Miri, Mir Mohammad, Sistanizad, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813193/
https://www.ncbi.nlm.nih.gov/pubmed/24250588
_version_ 1782289069808549888
author Kouchek, Mehran
Mansouri, Behnam
Mokhtari, Majid
Goharani, Reza
Miri, Mir Mohammad
Sistanizad, Mohammad
author_facet Kouchek, Mehran
Mansouri, Behnam
Mokhtari, Majid
Goharani, Reza
Miri, Mir Mohammad
Sistanizad, Mohammad
author_sort Kouchek, Mehran
collection PubMed
description Pain in ICU patients should be managed effectively and safely. Fentanyl and Paracetamol are used frequently in ICU. However experience using IV Paracetamol in the setting of critically ill patients is limited. We evaluated the analgesic effect and adverse reactions of intravenous Paracetamol compared to Fentanyl in ICU patients with mild to moderate pain. Forty patients in a general ICU were randomized into two groups of IV Paracetamol and IV Fentanyl in a single blinded fashion. Pain was assessed by Visual Analogue Scale (VAS) before drug administration and six hourly for 48 h of 1 g IV Paracetamol every 6 h for 48 h in the first group and 25 μg Fentanyl intravenously every three hours for 48 h in the second group. Patients were monitored for significant adverse reactions particularly of CNS and hepatic nature. Results showed the age, sex and pain score before analgesia was matched in both groups. Pain scores were similar in both groups at 24 h 2.60 (± 1.2) and 2.40 (± 1.5) and at 48 h 2.25 (± 0.96) and 2.05 (± 1.1) in Paracetamol and Fentanyl groups respectively. Clinical and laboratory adverse reactions were also similar in both groups. The analgesic properties of Paracetamol and Fentanyl were similar in this study. We did not observe any significant adverse effects in the two groups. Clinical and laboratory findings including liver functions remained without any statistically significant difference in two groups. This study demonstrates intravenous Paracetamol may be as safe and effective as Fentanyl in ICU patients with mild to moderate pain.
format Online
Article
Text
id pubmed-3813193
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Shaheed Beheshti University of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-38131932013-11-18 A Comparative Study of Intravenous Paracetamol and Fentanyl for Pain Management in ICU Kouchek, Mehran Mansouri, Behnam Mokhtari, Majid Goharani, Reza Miri, Mir Mohammad Sistanizad, Mohammad Iran J Pharm Res Original Article Pain in ICU patients should be managed effectively and safely. Fentanyl and Paracetamol are used frequently in ICU. However experience using IV Paracetamol in the setting of critically ill patients is limited. We evaluated the analgesic effect and adverse reactions of intravenous Paracetamol compared to Fentanyl in ICU patients with mild to moderate pain. Forty patients in a general ICU were randomized into two groups of IV Paracetamol and IV Fentanyl in a single blinded fashion. Pain was assessed by Visual Analogue Scale (VAS) before drug administration and six hourly for 48 h of 1 g IV Paracetamol every 6 h for 48 h in the first group and 25 μg Fentanyl intravenously every three hours for 48 h in the second group. Patients were monitored for significant adverse reactions particularly of CNS and hepatic nature. Results showed the age, sex and pain score before analgesia was matched in both groups. Pain scores were similar in both groups at 24 h 2.60 (± 1.2) and 2.40 (± 1.5) and at 48 h 2.25 (± 0.96) and 2.05 (± 1.1) in Paracetamol and Fentanyl groups respectively. Clinical and laboratory adverse reactions were also similar in both groups. The analgesic properties of Paracetamol and Fentanyl were similar in this study. We did not observe any significant adverse effects in the two groups. Clinical and laboratory findings including liver functions remained without any statistically significant difference in two groups. This study demonstrates intravenous Paracetamol may be as safe and effective as Fentanyl in ICU patients with mild to moderate pain. Shaheed Beheshti University of Medical Sciences 2013 /pmc/articles/PMC3813193/ /pubmed/24250588 Text en © 2013 by School of Pharmacy, Shaheed Beheshti University of Medical Sciences and Health Services This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kouchek, Mehran
Mansouri, Behnam
Mokhtari, Majid
Goharani, Reza
Miri, Mir Mohammad
Sistanizad, Mohammad
A Comparative Study of Intravenous Paracetamol and Fentanyl for Pain Management in ICU
title A Comparative Study of Intravenous Paracetamol and Fentanyl for Pain Management in ICU
title_full A Comparative Study of Intravenous Paracetamol and Fentanyl for Pain Management in ICU
title_fullStr A Comparative Study of Intravenous Paracetamol and Fentanyl for Pain Management in ICU
title_full_unstemmed A Comparative Study of Intravenous Paracetamol and Fentanyl for Pain Management in ICU
title_short A Comparative Study of Intravenous Paracetamol and Fentanyl for Pain Management in ICU
title_sort comparative study of intravenous paracetamol and fentanyl for pain management in icu
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813193/
https://www.ncbi.nlm.nih.gov/pubmed/24250588
work_keys_str_mv AT kouchekmehran acomparativestudyofintravenousparacetamolandfentanylforpainmanagementinicu
AT mansouribehnam acomparativestudyofintravenousparacetamolandfentanylforpainmanagementinicu
AT mokhtarimajid acomparativestudyofintravenousparacetamolandfentanylforpainmanagementinicu
AT goharanireza acomparativestudyofintravenousparacetamolandfentanylforpainmanagementinicu
AT mirimirmohammad acomparativestudyofintravenousparacetamolandfentanylforpainmanagementinicu
AT sistanizadmohammad acomparativestudyofintravenousparacetamolandfentanylforpainmanagementinicu
AT kouchekmehran comparativestudyofintravenousparacetamolandfentanylforpainmanagementinicu
AT mansouribehnam comparativestudyofintravenousparacetamolandfentanylforpainmanagementinicu
AT mokhtarimajid comparativestudyofintravenousparacetamolandfentanylforpainmanagementinicu
AT goharanireza comparativestudyofintravenousparacetamolandfentanylforpainmanagementinicu
AT mirimirmohammad comparativestudyofintravenousparacetamolandfentanylforpainmanagementinicu
AT sistanizadmohammad comparativestudyofintravenousparacetamolandfentanylforpainmanagementinicu