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Efficacy of Mupirocin and Rifampin Used with Standard Treatment in the Management of Acne Vulgaris
The multiple etiologic factors involved in acne make the use of various medications necessary to treat the condition. This study aimed to determine the efficacy of mupirocin and rifampin used with standard treatment in the management of acne vulgaris. In a multicentre, randomized controlled, triple-...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shaheed Beheshti University of Medical Sciences
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813198/ https://www.ncbi.nlm.nih.gov/pubmed/24250593 |
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author | Khorvash, Farzin Abdi, Fatemeh H.Kashani, Hessam Fatemi Naeini, Farahnaz Khorvash, Fariborz |
author_facet | Khorvash, Farzin Abdi, Fatemeh H.Kashani, Hessam Fatemi Naeini, Farahnaz Khorvash, Fariborz |
author_sort | Khorvash, Farzin |
collection | PubMed |
description | The multiple etiologic factors involved in acne make the use of various medications necessary to treat the condition. This study aimed to determine the efficacy of mupirocin and rifampin used with standard treatment in the management of acne vulgaris. In a multicentre, randomized controlled, triple-blinded study, a total of 105 acne patients, with a clinical diagnosis of moderate to severe acne,were randomizedly divided into three groups (35 per group), for treatment of acne. The first group was treated with standard treatment alone, the second group received mupirocin plus standard treatment and the third group received rifampin plus standard treatment.There were three study visits according to Global Acne Grading System (GAGS): at baseline and weeks 6 and 12. The absolute changes of GAGS score from baseline to week 6 and 12 demonstrated a reduction in the mean score of GAGS in the three treatment groups (p < 0.001). Due to the difference between GAGS score at the baseline of study, the data were adjusted using the general linear model. The findings showed that all of the treatments significantly improved acne lesions. Nevertheless, none of the treatments was shown to be more effective than the others (p = 0.9). The three treatments were well tolerated, and no serious adverse events were reported. These findings provide evidence on the efficacy of combining mupirocin and rifampin with standard treatment in the management of acne vulgaris, although none of the treatments had superior efficacy compared with the others. |
format | Online Article Text |
id | pubmed-3813198 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Shaheed Beheshti University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-38131982013-11-18 Efficacy of Mupirocin and Rifampin Used with Standard Treatment in the Management of Acne Vulgaris Khorvash, Farzin Abdi, Fatemeh H.Kashani, Hessam Fatemi Naeini, Farahnaz Khorvash, Fariborz Iran J Pharm Res Original Article The multiple etiologic factors involved in acne make the use of various medications necessary to treat the condition. This study aimed to determine the efficacy of mupirocin and rifampin used with standard treatment in the management of acne vulgaris. In a multicentre, randomized controlled, triple-blinded study, a total of 105 acne patients, with a clinical diagnosis of moderate to severe acne,were randomizedly divided into three groups (35 per group), for treatment of acne. The first group was treated with standard treatment alone, the second group received mupirocin plus standard treatment and the third group received rifampin plus standard treatment.There were three study visits according to Global Acne Grading System (GAGS): at baseline and weeks 6 and 12. The absolute changes of GAGS score from baseline to week 6 and 12 demonstrated a reduction in the mean score of GAGS in the three treatment groups (p < 0.001). Due to the difference between GAGS score at the baseline of study, the data were adjusted using the general linear model. The findings showed that all of the treatments significantly improved acne lesions. Nevertheless, none of the treatments was shown to be more effective than the others (p = 0.9). The three treatments were well tolerated, and no serious adverse events were reported. These findings provide evidence on the efficacy of combining mupirocin and rifampin with standard treatment in the management of acne vulgaris, although none of the treatments had superior efficacy compared with the others. Shaheed Beheshti University of Medical Sciences 2013 /pmc/articles/PMC3813198/ /pubmed/24250593 Text en © 2013 by School of Pharmacy, Shaheed Beheshti University of Medical Sciences and Health Services This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Khorvash, Farzin Abdi, Fatemeh H.Kashani, Hessam Fatemi Naeini, Farahnaz Khorvash, Fariborz Efficacy of Mupirocin and Rifampin Used with Standard Treatment in the Management of Acne Vulgaris |
title | Efficacy of Mupirocin and Rifampin Used with Standard Treatment in the Management of Acne Vulgaris |
title_full | Efficacy of Mupirocin and Rifampin Used with Standard Treatment in the Management of Acne Vulgaris |
title_fullStr | Efficacy of Mupirocin and Rifampin Used with Standard Treatment in the Management of Acne Vulgaris |
title_full_unstemmed | Efficacy of Mupirocin and Rifampin Used with Standard Treatment in the Management of Acne Vulgaris |
title_short | Efficacy of Mupirocin and Rifampin Used with Standard Treatment in the Management of Acne Vulgaris |
title_sort | efficacy of mupirocin and rifampin used with standard treatment in the management of acne vulgaris |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813198/ https://www.ncbi.nlm.nih.gov/pubmed/24250593 |
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