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Synthesis and Molecular-cellular Mechanistic Study of Pyridine Derivative of Dacarbazine

Dacarbazine is an antitumor prodrug which is used for the treatment of malignant metastatic melanoma and Hodgkin’s disease. It requires initial activation in liver through an N-demethylationreaction. The active metabolite prevents the progress of disease via alkylation of guanine bases in DNA strand...

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Detalles Bibliográficos
Autores principales:	Amirmostofian, Marzieh, Pourahmad Jaktaji, Jalal, Soleimani, Zohreh, Tabib, Kimia, Tanbakosazan, Farahnaz, Omrani, Mirdavood, Kobarfard, Farzad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Shaheed Beheshti University of Medical Sciences 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813268/ https://www.ncbi.nlm.nih.gov/pubmed/24250631

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