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Absolute Lymphocyte Count as a Predictor of Mortality in Emergency Department Patients with Paraquat Poisoning

BACKGROUND: Paraquat (PQ) is a potent, highly toxic and widely used herbicide. The major medical problems associated with PQ are accidental or suicidal ingestion. There are several prognostic markers of PQ poisoning, with the serum PQ concentration considered to be the best indicator of outcome. How...

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Autores principales: Kang, Changwoo, Kim, Seong Chun, Lee, Soo Hoon, Jeong, Jin Hee, Kim, Dong Seob, Kim, Dong Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813447/
https://www.ncbi.nlm.nih.gov/pubmed/24205140
http://dx.doi.org/10.1371/journal.pone.0078160
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author Kang, Changwoo
Kim, Seong Chun
Lee, Soo Hoon
Jeong, Jin Hee
Kim, Dong Seob
Kim, Dong Hoon
author_facet Kang, Changwoo
Kim, Seong Chun
Lee, Soo Hoon
Jeong, Jin Hee
Kim, Dong Seob
Kim, Dong Hoon
author_sort Kang, Changwoo
collection PubMed
description BACKGROUND: Paraquat (PQ) is a potent, highly toxic and widely used herbicide. The major medical problems associated with PQ are accidental or suicidal ingestion. There are several prognostic markers of PQ poisoning, with the serum PQ concentration considered to be the best indicator of outcome. However, the measurement of such markers is limited in many hospitals. OBJECTIVE: The present study was conducted to investigate the association of absolute lymphocyte count (ALC) and the 30-day mortality rate in patients with PQ poisoning. METHODS: We performed a retrospective analysis of patients admitted to the emergency department after paraquat poisoning between January 2010 and April 2013. Independent risk factors including ALC for 30-day mortality were determined. The ALC was categorized in quartiles as ≤1700, 1700 to 3200, 3200 to 5000, and >5000. Univariate and multivariate Cox proportional hazard analysis were performed to determine the independent risk factors for mortality. RESULTS: A total of 136 patients were included in the study, and the 30-day mortality was 73.5%. ALC was significantly higher in nonsurvivors than in survivors. The highest ALC quartile (ALC>5000; hazard ratio, 2.58; 95% CI, 1.08–6.21) was associated with increased mortality in multivariate analysis. In addition, old age, lower arterial PaCO(2), increased peripheral neutrophil count, and high serum levels of creatinine were associated with mortality. CONCLUSION: The absolute lymphocyte count is associated with the 30-day mortality rate in patients with paraquat poisoning.
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spelling pubmed-38134472013-11-07 Absolute Lymphocyte Count as a Predictor of Mortality in Emergency Department Patients with Paraquat Poisoning Kang, Changwoo Kim, Seong Chun Lee, Soo Hoon Jeong, Jin Hee Kim, Dong Seob Kim, Dong Hoon PLoS One Research Article BACKGROUND: Paraquat (PQ) is a potent, highly toxic and widely used herbicide. The major medical problems associated with PQ are accidental or suicidal ingestion. There are several prognostic markers of PQ poisoning, with the serum PQ concentration considered to be the best indicator of outcome. However, the measurement of such markers is limited in many hospitals. OBJECTIVE: The present study was conducted to investigate the association of absolute lymphocyte count (ALC) and the 30-day mortality rate in patients with PQ poisoning. METHODS: We performed a retrospective analysis of patients admitted to the emergency department after paraquat poisoning between January 2010 and April 2013. Independent risk factors including ALC for 30-day mortality were determined. The ALC was categorized in quartiles as ≤1700, 1700 to 3200, 3200 to 5000, and >5000. Univariate and multivariate Cox proportional hazard analysis were performed to determine the independent risk factors for mortality. RESULTS: A total of 136 patients were included in the study, and the 30-day mortality was 73.5%. ALC was significantly higher in nonsurvivors than in survivors. The highest ALC quartile (ALC>5000; hazard ratio, 2.58; 95% CI, 1.08–6.21) was associated with increased mortality in multivariate analysis. In addition, old age, lower arterial PaCO(2), increased peripheral neutrophil count, and high serum levels of creatinine were associated with mortality. CONCLUSION: The absolute lymphocyte count is associated with the 30-day mortality rate in patients with paraquat poisoning. Public Library of Science 2013-10-24 /pmc/articles/PMC3813447/ /pubmed/24205140 http://dx.doi.org/10.1371/journal.pone.0078160 Text en © 2013 Kang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Kang, Changwoo
Kim, Seong Chun
Lee, Soo Hoon
Jeong, Jin Hee
Kim, Dong Seob
Kim, Dong Hoon
Absolute Lymphocyte Count as a Predictor of Mortality in Emergency Department Patients with Paraquat Poisoning
title Absolute Lymphocyte Count as a Predictor of Mortality in Emergency Department Patients with Paraquat Poisoning
title_full Absolute Lymphocyte Count as a Predictor of Mortality in Emergency Department Patients with Paraquat Poisoning
title_fullStr Absolute Lymphocyte Count as a Predictor of Mortality in Emergency Department Patients with Paraquat Poisoning
title_full_unstemmed Absolute Lymphocyte Count as a Predictor of Mortality in Emergency Department Patients with Paraquat Poisoning
title_short Absolute Lymphocyte Count as a Predictor of Mortality in Emergency Department Patients with Paraquat Poisoning
title_sort absolute lymphocyte count as a predictor of mortality in emergency department patients with paraquat poisoning
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813447/
https://www.ncbi.nlm.nih.gov/pubmed/24205140
http://dx.doi.org/10.1371/journal.pone.0078160
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