The Inhibition of Subchondral Bone Lesions Significantly Reversed the Weight-Bearing Deficit and the Overexpression of CGRP in DRG Neurons, GFAP and Iba-1 in the Spinal Dorsal Horn in the Monosodium Iodoacetate Induced Model of Osteoarthritis Pain

BACKGROUND: Chronic pain is the most prominent and disabling symptom of osteoarthritis (OA). Clinical data suggest that subchondral bone lesions contribute to the occurrence of joint pain. The present study investigated the effect of the inhibition of subchondral bone lesions on joint pain. METHODS:...

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Detalles Bibliográficos
Autores principales: Yu, Degang, Liu, Fengxiang, Liu, Ming, Zhao, Xin, Wang, Xiaoqing, Li, Yang, Mao, Yuanqing, Zhu, Zhenan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813732/
https://www.ncbi.nlm.nih.gov/pubmed/24204985
http://dx.doi.org/10.1371/journal.pone.0077824

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