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Extraventricular neurocytoma in pediatric populations: A case report and review of the literature
Extraventricular neurocytomas (EVNs) are rare neuronal tumors included in the definition of neoplasms in the 2007 World Health Organization classification of tumors of the central nervous system. Although a small case series of EVNs in adults has been previously reported, EVNs in pediatric populatio...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813794/ https://www.ncbi.nlm.nih.gov/pubmed/24179531 http://dx.doi.org/10.3892/ol.2013.1583 |
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author | HAN, LIN NIU, HONGQUAN WANG, JUNWEN WAN, FENG SHU, KAI KE, CHANGSHU LEI, TING |
author_facet | HAN, LIN NIU, HONGQUAN WANG, JUNWEN WAN, FENG SHU, KAI KE, CHANGSHU LEI, TING |
author_sort | HAN, LIN |
collection | PubMed |
description | Extraventricular neurocytomas (EVNs) are rare neuronal tumors included in the definition of neoplasms in the 2007 World Health Organization classification of tumors of the central nervous system. Although a small case series of EVNs in adults has been previously reported, EVNs in pediatric populations are extremely rare. The current case report presents the clinicopathological features of an EVN in a 2-year-old female who presented with nausea and vomiting that had lasted for five days. In addition, an analysis of the imaging features, histology, treatment and prognosis of these reported rare lesions is presented. Immunohistochemically, EVNs are characterized by the robust expression of synaptophysin, but with a lack of oligodendrocyte transcription factor 2, isocitrate dehydrogenase enzyme isoform 1 (IDH1) R132/IDH2 R172 mutations and p53 immunoexpression. The treatment for EVNs in pediatric and adult populations is gross total resection, with post-operative radiation reserved for subtotal resection or recurrent disease. In addition, drop metastasis must be carefully avoided. |
format | Online Article Text |
id | pubmed-3813794 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-38137942013-10-31 Extraventricular neurocytoma in pediatric populations: A case report and review of the literature HAN, LIN NIU, HONGQUAN WANG, JUNWEN WAN, FENG SHU, KAI KE, CHANGSHU LEI, TING Oncol Lett Articles Extraventricular neurocytomas (EVNs) are rare neuronal tumors included in the definition of neoplasms in the 2007 World Health Organization classification of tumors of the central nervous system. Although a small case series of EVNs in adults has been previously reported, EVNs in pediatric populations are extremely rare. The current case report presents the clinicopathological features of an EVN in a 2-year-old female who presented with nausea and vomiting that had lasted for five days. In addition, an analysis of the imaging features, histology, treatment and prognosis of these reported rare lesions is presented. Immunohistochemically, EVNs are characterized by the robust expression of synaptophysin, but with a lack of oligodendrocyte transcription factor 2, isocitrate dehydrogenase enzyme isoform 1 (IDH1) R132/IDH2 R172 mutations and p53 immunoexpression. The treatment for EVNs in pediatric and adult populations is gross total resection, with post-operative radiation reserved for subtotal resection or recurrent disease. In addition, drop metastasis must be carefully avoided. D.A. Spandidos 2013-11 2013-09-12 /pmc/articles/PMC3813794/ /pubmed/24179531 http://dx.doi.org/10.3892/ol.2013.1583 Text en Copyright © 2013, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Articles HAN, LIN NIU, HONGQUAN WANG, JUNWEN WAN, FENG SHU, KAI KE, CHANGSHU LEI, TING Extraventricular neurocytoma in pediatric populations: A case report and review of the literature |
title | Extraventricular neurocytoma in pediatric populations: A case report and review of the literature |
title_full | Extraventricular neurocytoma in pediatric populations: A case report and review of the literature |
title_fullStr | Extraventricular neurocytoma in pediatric populations: A case report and review of the literature |
title_full_unstemmed | Extraventricular neurocytoma in pediatric populations: A case report and review of the literature |
title_short | Extraventricular neurocytoma in pediatric populations: A case report and review of the literature |
title_sort | extraventricular neurocytoma in pediatric populations: a case report and review of the literature |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813794/ https://www.ncbi.nlm.nih.gov/pubmed/24179531 http://dx.doi.org/10.3892/ol.2013.1583 |
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